Evidence map›Paper›PMID 35887048›Full record

ReviewInternational journal of molecular sciences2022

Mitochondrial a Kinase Anchor Proteins in Cardiovascular Health and Disease: A Review Article on Behalf of the Working Group on Cellular and Molecular Biology of the Heart of the Italian Society of Cardiology.

Roberta Paolillo, Stefania D'Apice, Gabriele Giacomo Schiattarella, Pietro Ameri, Domenica Borzacchiello, Daniele Catalucci, Cristina Chimenti, Lia Crotti, Sebastiano Sciarretta, Daniele Torella and 2 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Recent advances in novel targeting mechanisms for colorectal cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  3. Review
  4. Review
  5. Advances inJournal of fungi (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Roberta PaolilloDepartment of Advanced Biomedical Sciences, Federico II University, 80131 Naples, Italy.
Stefania D'ApiceDepartment of Advanced Biomedical Sciences, Federico II University, 80131 Naples, Italy.
Gabriele Giacomo SchiattarellaDepartment of Advanced Biomedical Sciences, Federico II University, 80131 Naples, Italy.
Pietro AmeriDepartment of Internal Medicine, University of Genova, 16132 Genova, Italy.
Domenica BorzacchielloDepartment of Molecular Medicine and Medical Biotechnology, Federico II University, 80131 Naples, Italy.
Daniele CatalucciInstitute of Genetic and Biomedical Research (IRGB), National Research Council (CNR), Milan Unit, 20133 Milan, Italy.ORCID 0000-0001-7041-6114
Cristina ChimentiDepartment of Clinical Medicine, Anesthesiology and Cardiovascular Sciences, University of Rome "La Sapienza", 00161 Rome, Italy.
Lia CrottiDepartment of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
Sebastiano SciarrettaDepartment of Medical and Surgical Sciences and Biotechnologies, University of Rome "La Sapienza", 04100 Rome, Italy.
Daniele TorellaDepartment of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.
Antonio FelicielloDepartment of Molecular Medicine and Medical Biotechnology, Federico II University, 80131 Naples, Italy.
Cinzia PerrinoDepartment of Advanced Biomedical Sciences, Federico II University, 80131 Naples, Italy.ORCID 0000-0002-2274-0048
Federico II University Hospital · ITInstitute of Genetic and Biomedical Research · ITIRCCS Istituto Auxologico Italiano · ITIstituto Neurologico Mediterraneo · ITMagna Graecia University · ITSapienza University of Rome · ITUniversity of Genoa · IT

Funding

Italian Ministry of University and Research (PRIN 2020) 2020YRETTX
6 · The paper itself

Abstract

Second messenger cyclic adenosine monophosphate (cAMP) has been found to regulate multiple mitochondrial functions, including respiration, dynamics, reactive oxygen species production, cell survival and death through the activation of cAMP-dependent protein kinase A (PKA) and other effectors. Several members of the large family of A kinase anchor proteins (AKAPs) have been previously shown to locally amplify cAMP/PKA signaling to mitochondria, promoting the assembly of signalosomes, regulating multiple cardiac functions under both physiological and pathological conditions. In this review, we will discuss roles and regulation of major mitochondria-targeted AKAPs, along with opportunities and challenges to modulate their functions for translational purposes in the cardiovascular system.

Indexed as

A Kinase Anchor ProteinsCardiologyCyclic AMPHeartMitochondriaMolecular BiologyA Kinase Anchor ProteinsCyclic AMPAKAP1AKAPscAMPmitochondriaprotein kinase AROS

Identifiers

PMID35887048
PMCPMC9322728
OpenAlexW4285094235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.