Evidence map›Paper›PMID 35887046›Full record

ArticleInternational journal of molecular sciences2022

Effects of Combined Allogenic Adipose Stem Cells and Hyperbaric Oxygenation Treatment on Pathogenesis of Osteoarthritis in Knee Joint Induced by Monoiodoacetate.

Aleksandar Juskovic, Marina Nikolic, Biljana Ljujic, Aleksandar Matic, Vladimir Zivkovic, Ksenija Vucicevic, Zoran Milosavljevic, Radisa Vojinovic, Nemanja Jovicic, Suzana Zivanovic and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Mediators of inflammation · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Aleksandar JuskovicDepartment of Orthopaedic Surgery, Clinical Centre of Montenegro, 81110 Podgorica, Montenegro.
Marina NikolicDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.ORCID 0000-0001-7829-5812
Biljana LjujicDepartment of Genetics, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Aleksandar MaticDepartment of Surgery, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.ORCID 0000-0002-3023-0478
Vladimir ZivkovicDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Ksenija VucicevicDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Zoran MilosavljevicDepartment of Histology and Embriology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Radisa VojinovicUniversity Clinical Center, 34000 Kragujevac, Serbia.ORCID 0000-0002-3213-1596
Nemanja JovicicDepartment of Histology and Embriology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.ORCID 0000-0003-1697-8380
Suzana ZivanovicDepartment of Dentistry, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
Nevena MilivojevicLaboratory for Bioengineering, Institute of Information Technologies Kragujevac, Department of Natural and Mathematical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.ORCID 0000-0002-4518-1066
Vladimir JakovljevicDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.ORCID 0000-0002-0071-8376
Sergey BolevichDepartment of Human Pathology, First Moscow State Medical University I.M. Sechenov, 119991 Moscow, Russia.
Marina Miletic KovacevicDepartment of Histology and Embriology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
University of Kragujevac · RSSechenov University · RUUniversity of Montenegro · ME

Funding

Faculty of Medical Sciences, University of Kragujevac, Serbia JP 25/19; JP 06/20 and JP 24/20Ministry of Education, Science and Technological Development of the Republic of Serbia 175103
6 · The paper itself

Abstract

The beneficial effects of HBO in inflammatory processes make it an attractive type of treatment for chronic arthritis. In addition, the effects of combination therapy based on adipose stem cells and HBO on OA progression have not been fully investigated. The current study explored the efficacy of intra-articular injection of allogeneic adipose-derived mesenchymal stem cells (ADMSCs) combined with hyperbaric oxygenation treatment (HBO) in a rat osteoarthritis (OA) model. The rat OA model was induced by intra-articular injection of monoiodoacetate (MIA) and 7 days after application of MIA rats were divided into five groups: healthy control (CTRL), osteoarthritis (OA), ADMSCs (ADS), the HBO+ADS

Indexed as

Cartilage, ArticularHyperbaric OxygenationOsteoarthritisOsteoarthritis, KneeAnimalsDisease Models, AnimalHumansInjections, Intra-ArticularKnee JointRatsStem CellsADMSCsHBOmonoiodoacetateosteoarthritisrats

Identifiers

PMID35887046
PMCPMC9317268
OpenAlexW4285092383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.