Evidence map›Paper›PMID 35887000›Full record

ArticleInternational journal of molecular sciences2022

Discovery of Long Non-Coding RNA MALAT1 Amplification in Precancerous Colorectal Lesions.

Anna Siskova, Jan Kral, Jana Drabova, Klara Cervena, Kristyna Tomasova, Jiri Jungwirth, Tomas Hucl, Pavel Kohout, Sandra Summerova, Ludmila Vodickova and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. International journal of general medicine · 2023
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Anna SiskovaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague, Czech Republic.ORCID 0000-0001-7101-5742
Jan KralClinic of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21 Prague, Czech Republic.ORCID 0000-0001-6960-1013
Jana DrabovaDepartment of Biology and Medical Genetics, 2nd Faculty of Medicine, Charles University and University Hospital Motol, V Uvalu 84, 150 06 Prague, Czech Republic.
Klara CervenaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague, Czech Republic.ORCID 0000-0002-0948-0130
Kristyna TomasovaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague, Czech Republic.
Jiri JungwirthInstitute of Physiology, 1st Faculty of Medicine Charles University, Katerinska 1660/32, 121 08 Praha, Czech Republic.
Tomas HuclClinic of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, Videnska 1958/9, 140 21 Prague, Czech Republic.
Pavel KohoutDepartment of Internal Medicine, 3rd Faculty of Medicine University and Faculty Thomayer Hospital Prague, Ruska 87, 100 00 Prague, Czech Republic.
Sandra SummerovaDepartment of Internal Medicine, 3rd Faculty of Medicine University and Faculty Thomayer Hospital Prague, Ruska 87, 100 00 Prague, Czech Republic.
Ludmila VodickovaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague, Czech Republic.
Pavel VodickaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague, Czech Republic.
Veronika VymetalkovaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 00 Prague, Czech Republic.ORCID 0000-0001-6870-6788
Charles University · CZInstitute of Clinical and Experimental Medicine · CZThomayer University Hospital · CZ

Funding

Cooperatio Program Oncology and HaematologyGrant Agency of the Czech Republic GACR 22-05942SGrant Agency of the Ministry of Health of the Czech Republic AZV NV18-03-00199Grant Schemes project at UK CZ.02.2.69/0.0/0.0/19_073 project n. START/MED/052
6 · The paper itself

Abstract

A colorectal adenoma, an aberrantly growing tissue, arises from the intestinal epithelium and is considered as precursor of colorectal cancer (CRC). In this study, we investigated structural and numerical chromosomal aberrations in adenomas, hypothesizing that chromosomal instability (CIN) occurs early in adenomas. We applied array comparative genomic hybridization (aCGH) to fresh frozen colorectal adenomas and their adjacent mucosa from 16 patients who underwent colonoscopy examination. In our study, histologically similar colorectal adenomas showed wide variability in chromosomal instability. Based on the obtained results, we further stratified patients into four distinct groups. The first group showed the gain of

Indexed as

AdenomaColorectal NeoplasmsPrecancerous ConditionsRNA, Long NoncodingChromosomal InstabilityComparative Genomic HybridizationHumansMALAT1 long non-coding RNA, humanRNA, Long Noncodingadenomasarray comparative genomic hybridizationcolorectal cancerlong non-coding RNAMALAT1

Identifiers

PMID35887000
PMCPMC9318831
OpenAlexW4285043220

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.