Evidence map›Paper›PMID 35886945›Full record

ReviewInternational journal of molecular sciences2022

Toxicologic Concerns with Current Medical Nanoparticles.

Tsai-Mu Cheng, Hsiu-Yi Chu, Haw-Ming Huang, Zi-Lin Li, Chiang-Ying Chen, Ya-Jung Shih, Jacqueline Whang-Peng, R Holland Cheng, Ju-Ku Mo, Hung-Yun Lin and 1 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Toxicity of nanostructures in drug delivery applications.Pharmaceutical science advances · 2026
    Review
  3. Review
  4. Highly Biomimetic Ectodermal Epithelial Organoids for Epithelial Barrier Stimulation Assays.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Rosemary essenitial oil counters MnOScientific reports · 2025
    Article
  10. Review
  11. Carbon nanotubes for wound healing: material design, mechanistic insights.Frontiers in bioengineering and biotechnology · 2025
    Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tsai-Mu ChengGraduate Institute for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0002-5712-3920
Hsiu-Yi ChuGraduate Institute for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Haw-Ming HuangSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0003-4184-3744
Zi-Lin LiGraduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
Chiang-Ying ChenGraduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
Ya-Jung ShihGraduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan.
Jacqueline Whang-PengCancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.
R Holland ChengDepartment of Molecular & Cellular Biology, University of California, Davis, CA 95616, USA.ORCID 0000-0002-2068-7271
Ju-Ku MoGraduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan.
Hung-Yun LinCancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan.
Kuan WangGraduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan.

Funding

Cell-specific nanocarrier with endocytic and endosomolytic activities for therapeutic genome editingUG3TR002866 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHENG, R.HOLLAND, LAM, KIT S · 2019 to 2021
$2.3M
Spatiotemporal Gene Regulation and KSHV ReplicationR01CA225266 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI IZUMIYA, YOSHIHIRO · 2018 to 2022
$1.8M
Genetically Encoded Small Illuminants for 4D nucleome imagingU01EB021230 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHENG, R.HOLLAND, IZUMIYA, YOSHIHIRO · 2015 to 2017
$990k
Integrated grant from the Ministry of Science and Technology, Taiwan MOST110-2314-B-038-114Integrated grant from the Ministry of Science and Technology, Taiwan MOST110-2314-B-038-115Integrated grant from the Ministry of Science and Technology, Taiwan MOST110-2314-B-038-119Ministry of Education, Taiwan DP2-107-20000Ministry of Science and Technology, Taiwan MOST109-2314-B-038-125Ministry of Science and Technology, Taiwan MOST 110-2314-B-038-031NCATS NIH HHS UG3 TR002866NCI NIH HHS R01 CA225266NIBIB NIH HHS U01 EB021230
6 · The paper itself

Abstract

Nanotechnology is one of the scientific advances in technology. Nanoparticles (NPs) are small materials ranging from 1 to 100 nm. When the shape of the supplied nanoparticles changes, the physiological response of the cells can be very different. Several characteristics of NPs such as the composition, surface chemistry, surface charge, and shape are also important parameters affecting the toxicity of nanomaterials. This review covered specific topics that address the effects of NPs on nanomedicine. Furthermore, mechanisms of different types of nanomaterial-induced cytotoxicities were described. The distributions of different NPs in organs and their adverse effects were also emphasized. This review provides insight into the scientific community interested in nano(bio)technology, nanomedicine, and nanotoxicology. The content may also be of interest to a broad range of scientists.

Indexed as

NanoparticlesNanomedicineNanotechnologycytotoxicityingestioninhalationmedical applicationsnanoparticlesnanotoxicity

Identifiers

PMID35886945
PMCPMC9322368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.