Evidence map›Paper›PMID 35886853›Full record

ArticleInternational journal of molecular sciences2022

Medicinal Hypervalent Tellurium Prodrugs Bearing Different Ligands: A Comparative Study of the Chemical Profiles of AS101 and Its Halido Replaced Analogues.

Lorenzo Chiaverini, Damiano Cirri, Iogann Tolbatov, Francesca Corsi, Ilaria Piano, Alessandro Marrone, Alessandro Pratesi, Tiziano Marzo, Diego La Mendola

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Lorenzo ChiaveriniDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano, 6, 56126 Pisa, Italy.ORCID 0000-0003-4857-9819
Damiano CirriDepartment of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi, 13, 56124 Pisa, Italy.ORCID 0000-0001-9175-9562
Iogann TolbatovInstitute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, 43007 Tarragona, Spain.ORCID 0000-0001-9700-5331
Francesca CorsiDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano, 6, 56126 Pisa, Italy.ORCID 0000-0002-9350-7948
Ilaria PianoDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano, 6, 56126 Pisa, Italy.
Alessandro MarroneDipartimento di Farmacia, Università degli Studi "G. D'Annunzio" Chieti-Pescara, Via dei Vestini, 66100 Chieti, Italy.ORCID 0000-0002-8311-8172
Alessandro PratesiDepartment of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi, 13, 56124 Pisa, Italy.ORCID 0000-0002-9553-9943
Tiziano MarzoDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano, 6, 56126 Pisa, Italy.ORCID 0000-0002-2567-3637
Diego La MendolaDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano, 6, 56126 Pisa, Italy.ORCID 0000-0002-4193-7612
University of Pisa · ITInstitut Català d'Investigació Química · ESUniversity of Chieti-Pescara · IT

Funding

Beneficentia Stiftung, Vaduz (BEN2019/48)University of Pisa PRA - Progetti di Ricerca di Ateneo" Institutional Research Grants - Project no. PRA_2020_58 "Agenti innovativi e nanosistemi per target molecolari nell'ambito dell'oncologia di precisione".
6 · The paper itself

Abstract

Ammonium trichloro (dioxoethylene-O,O') tellurate (AS101) is a potent immunomodulator prodrug that, in recent years, entered various clinical trials and was tested for a variety of potential therapeutic applications. It has been demonstrated that AS101 quickly activates in aqueous milieu, producing TeOCl

Indexed as

ProdrugsAdjuvants, ImmunologicEthylenesLigandsTelluriumAdjuvants, Immunologicammonium trichloro(dioxoethylene-O,O'-)tellurateEthylenesLigandsProdrugsTelluriumAS101bioinorganic chemistryclinical trialscoordination chemistryinorganic drugsmetalloidsprodrugstellurium

Identifiers

PMID35886853
PMCPMC9317073
OpenAlexW4283836135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.