ArticleInternational journal of environmental research and public health2022
Occupational Exposure Assessment to Antineoplastic Drugs in Nine Italian Hospital Centers over a 5-Year Survey Program.
Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Development and application of a wipe sampling method for detection of antibiotic surface contamination in hospital wards.Annals of work exposures and health · 2026Article
- Cross-Sectional Multicenter Biomonitoring Study on Genotoxicity and Oxidative DNA Damage in Oncology Healthcare Workers from Seven Italian Hospitals.Journal of xenobiotics · 2026Article
- Buccal micronucleus cytome assay to evaluate cyto-genotoxic effects of occupational exposure to antineoplastic drugs: application on a large sample size of workers furnished by an Italian network of oncological hospitals.Archives of toxicology · 2025Article
- Assessing Etoposide and Cyclophosphamide Contamination and Current Cleaning Practices in Patient Bathrooms.Clinical journal of oncology nursing · 2025Article
- Application of a multifunctional chemotherapy infusion device for reducing antineoplastic drug extravasation.Frontiers in oncology · 2025Article
- An Automated Micro Solid-Phase Extraction (μSPE) Liquid Chromatography-Mass Spectrometry Method for Cyclophosphamide and Iphosphamide: Biological Monitoring in Antineoplastic Drug (AD) Occupational Exposure.Molecules (Basel, Switzerland) · 2024Article
- Evaluation of long-term data on surface contamination by antineoplastic drugs in pharmacies.International archives of occupational and environmental health · 2023Article
- Occupational Exposure to Antineoplastic Drugs in Twelve French Health Care Setting: Biological Monitoring and Surface Contamination.International journal of environmental research and public health · 2023Article
- Proposals of guidance values for surface contamination by antineoplastic drugs based on long term monitoring in Czech and Slovak hospitals and pharmacies.Frontiers in public health · 2023Article
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12 authors.
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Abstract
In the present study, surface contamination where antineoplastic drugs (ADs) are present was investigated, as occupational exposure risk is still an open debate. Despite recommendations and safety standard procedures being in place in health care settings, quantifiable levels of ADs are being reported in the recent literature. Thus, a survey monitoring program was conducted over five years (2016-2021) in nine Italian hospitals. The repeated surveys produced 8288 data points that have been grouped according to the main hospital settings, such as pharmacy areas and patient care units. Based on the most often prepared ADs, the investigated drugs were cyclophosphamide (CP), gemcitabine (GEM), 5-fluorouracil (5-FU), and platinum compounds (Pt). Patient care units had a frequency of positive wipe samples (59%) higher than pharmacies (44%). Conversely, pharmacies had a frequency of positive pad samples higher (24%) than patient care units (10%). Moreover, by statistical analysis, pad samples had a significantly higher risk of contamination in pharmacy areas than in patient care units. In this study, the 75th and the 90th percentiles of the contamination levels were obtained. The 90th percentile was chosen to describe a suitable benchmark that compares results obtained by the present research with those previously reported in the literature. Based upon surface contamination loads, our data showed that 5-FU had the highest concentration values, but the lowest frequency of positive samples. In pharmacy areas, the 90th percentile of 5-FU data distribution was less than 0.346 ng/cm
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