Evidence map›Paper›PMID 35886072›Full record

ReviewGenes2022

The Epitranscriptome in miRNAs: Crosstalk, Detection, and Function in Cancer.

Daniel Del Valle-Morales, Patricia Le, Michela Saviana, Giulia Romano, Giovanni Nigita, Patrick Nana-Sinkam, Mario Acunzo

Abstract readReview
In one paragraph

Review in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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  6. Review
  7. Article
  8. [Tumor-associated fibroblasts promotes proliferation and migration of prostate cancer cells by suppressing FBXL3Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel Del Valle-MoralesDivision of Pulmonary Diseases and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
Patricia LeDivision of Pulmonary Diseases and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.ORCID 0000-0002-9344-1301
Michela SavianaDivision of Pulmonary Diseases and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
Giulia RomanoDivision of Pulmonary Diseases and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
Giovanni NigitaComprehensive Cancer Center, Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-8880-4334
Patrick Nana-SinkamDivision of Pulmonary Diseases and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.
Mario AcunzoDivision of Pulmonary Diseases and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Renato Martins · 1985 to 2026
$51.0M
Virginia Commonwealth University IRADCAK12GM093857 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI DANIEL C BULLARD, John J Ryan · 2010 to 2026
$7.0M
Institutional Career Development CoreKL2TR002648 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI NANASINKAM, SERGE PATRICK, SANYAL, ARUN J · 2018 to 2022
$3.7M
Translational Research Center in Lung Cancer Disparities (TRACER)P20CA252717 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI SEEWALDT, VICTORIA L. · 2021 to 2023
$3.2M
Extracellular Vesicles in Small Cell Lung Cancer Early DetectionU01CA213330 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI LEE, LY JAMES, NANASINKAM, SERGE PATRICK · 2017 to 2021
$2.7M
NCATS NIH HHS KL2 TR002648NCI NIH HHS P20 CA252717NCI NIH HHS P30 CA016059NCI NIH HHS U01 CA213330NIGMS NIH HHS K12 GM093857
6 · The paper itself

Abstract

The epitranscriptome encompasses all post-transcriptional modifications that occur on RNAs. These modifications can alter the function and regulation of their RNA targets, which, if dysregulated, result in various diseases and cancers. As with other RNAs, miRNAs are highly modified by epitranscriptomic modifications such as m

Indexed as

MicroRNAsNeoplasmsHumansMethylationRNA Processing, Post-TranscriptionalMicroRNAscancerepitranscriptomicsmiRNA

Identifiers

PMID35886072
PMCPMC9316458

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.