Evidence map›Paper›PMID 35886037›Full record

ReviewGenes2022

Emerging Roles and Potential Applications of Non-Coding RNAs in Cervical Cancer.

Deepak Parashar, Anupam Singh, Saurabh Gupta, Aishwarya Sharma, Manish K Sharma, Kuldeep K Roy, Subhash C Chauhan, Vivek K Kashyap

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Deepak ParasharDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, MI 53226, USA.ORCID 0000-0002-5062-8950
Anupam SinghDepartment of Biotechnology, GLA University, Mathura 281406, Uttar Pradesh, India.
Saurabh GuptaDepartment of Biotechnology, GLA University, Mathura 281406, Uttar Pradesh, India.ORCID 0000-0001-8140-2033
Aishwarya SharmaSri Siddhartha Medical College and Research Center, Tumkur 572107, Karnataka, India.
Manish K SharmaDepartment of Biotechnology, IP College, Bulandshahr 203001, Uttar Pradesh, India.
Kuldeep K RoyDepartment of Pharmaceutical Sciences, School of Health Sciences and Technology, UPES, Dehradun 248007, Uttarakhand, India.
Subhash C ChauhanDepartment of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
Vivek K KashyapDepartment of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
GLA University · INThe University of Texas Rio Grande Valley · USMedical College of Wisconsin · USSri Siddhartha Medical College · INUniversity of Petroleum and Energy Studies · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer (CC) is a preventable disease using proven interventions, specifically prophylactic vaccination, pervasive disease screening, and treatment, but it is still the most frequently diagnosed cancer in women worldwide. Patients with advanced or metastatic CC have a very dismal prognosis and current therapeutic options are very limited. Therefore, understanding the mechanism of metastasis and discovering new therapeutic targets are crucial. New sequencing tools have given a full visualization of the human transcriptome's composition. Non-coding RNAs (NcRNAs) perform various functions in transcriptional, translational, and post-translational processes through their interactions with proteins, RNA, and even DNA. It has been suggested that ncRNAs act as key regulators of a variety of biological processes, with their expression being tightly controlled under physiological settings. In recent years, and notably in the past decade, significant effort has been made to examine the role of ncRNAs in a variety of human diseases, including cancer. Therefore, shedding light on the functions of ncRNA will aid in our better understanding of CC. In this review, we summarize the emerging roles of ncRNAs in progression, metastasis, therapeutics, chemo-resistance, human papillomavirus (HPV) regulation, metabolic reprogramming, diagnosis, and as a prognostic biomarker of CC. We also discussed the role of ncRNA in the tumor microenvironment and tumor immunology, including cancer stem cells (CSCs) in CC. We also address contemporary technologies such as antisense oligonucleotides, CRISPR-Cas9, and exosomes, as well as their potential applications in targeting ncRNAs to manage CC.

Indexed as

ExosomesUterine Cervical NeoplasmsFemaleHumansNeoplastic Stem CellsPrognosisRNA, UntranslatedTumor MicroenvironmentRNA, Untranslatedcervical cancerdiagnosisnon-coding RNAsprognosisregulation of gene expressiontherapeutics

Identifiers

PMID35886037
PMCPMC9317009
OpenAlexW4285733654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.