ArticleGenes2022
MicrobiomeGWAS: A Tool for Identifying Host Genetic Variants Associated with Microbiome Composition.
Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Complex correlations between mitochondrial DNA variants and gut microbiome in major depressive disorder: a genome-wide association analysis.BMC psychiatry · 2026Article
- The crosstalk between host and rumen microbiome in cattle: insights from multi-omics approaches and genome-wide association studies.World journal of microbiology & biotechnology · 2025Review
- Review
- Exploring the Interplay between the Hologenome and Complex Traits in Bovine and Porcine Animals Using Genome-Wide Association Analysis.International journal of molecular sciences · 2024Article
- Review
- Review
- Kernel-based genetic association analysis for microbiome phenotypes identifies host genetic drivers of beta-diversity.Microbiome · 2023Article
- The host genetics affects gut microbiome diversity in Chinese depressed patients.Frontiers in genetics · 2022Article
- Host, pathogenic fungi and the microbiome: A genetic triangle in infection.Frontiers in immunology · 2022Article
- A Statistical Method for Association Analysis of Cell Type Compositions.Statistics in biosciences · 2021Article
- A genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases.Cell discovery · 2021Article
- Heritable Gut Microbiome Associated withmSystems · 2021Article
- Genome-wide association studies and heritability analysis reveal the involvement of host genetics in the Japanese gut microbiota.Communications biology · 2020Article
- The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases.Microbiome · 2020Article
- A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals.Microbiome · 2019Article
- Host and microbiome multi-omics integration: applications and methodologies.Biophysical reviews · 2019Review
- Tantalizing dilemma in risk prediction from disease scoring statistics.Briefings in functional genomics · 2018Review
- Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci.Gut microbes · 2018Article
- Host and Microbiome Genome-Wide Association Studies: Current State and Challenges.Frontiers in genetics · 2018Review
- The Relationship Between the Human Genome and Microbiome Comes into View.Annual review of genetics · 2017Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microbiome is the collection of all microbial genes and can be investigated by sequencing highly variable regions of 16S ribosomal RNA (rRNA) genes. Evidence suggests that environmental factors and host genetics may interact to impact human microbiome composition. Identifying host genetic variants associated with human microbiome composition not only provides clues for characterizing microbiome variation but also helps to elucidate biological mechanisms of genetic associations, prioritize genetic variants, and improve genetic risk prediction. Since a microbiota functions as a community, it is best characterized by β diversity; that is, a pairwise distance matrix. We develop a statistical framework and a computationally efficient software package, microbiomeGWAS, for identifying host genetic variants associated with microbiome β diversity with or without interacting with an environmental factor. We show that the score statistics have positive skewness and kurtosis due to the dependent nature of the pairwise data, which makes
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Registered trials
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