Evidence map›Paper›PMID 35885978›Full record

ArticleGenes2022

Transcriptional Interference Regulates the Evolutionary Development of Speech.

Douglas P Mortlock, Zhi-Ming Fang, Kelly J Chandler, Yue Hou, Lissett R Bickford, Charles E de Bock, Valsamma Eapen, Raymond A Clarke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Douglas P MortlockDepartment of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232-0700, USA.
Zhi-Ming FangDiscipline of Psychiatry, Ingham Institute, University of New South Wales, 1 Campbell Street Liverpool, Sydney, NSW 2170, Australia.
Kelly J ChandlerDepartment of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232-0700, USA.
Yue HouDepartment of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232-0700, USA.
Lissett R BickfordDepartment of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University School of Medicine, Nashville, TN 37232-0700, USA.
Charles E de BockChildren's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Kensington, NSW 2052, Australia.
Valsamma EapenDiscipline of Psychiatry, Ingham Institute, University of New South Wales, 1 Campbell Street Liverpool, Sydney, NSW 2170, Australia.ORCID 0000-0001-6296-8306
Raymond A ClarkeDiscipline of Psychiatry, Ingham Institute, University of New South Wales, 1 Campbell Street Liverpool, Sydney, NSW 2170, Australia.ORCID 0000-0002-7196-9623
UNSW Sydney · AUVanderbilt University · US

Funding

Training Program on Genetic Variation and Human PhenotypesT32GM080178 · NIGMS · VANDERBILT UNIVERSITY · PI COX, NANCY J, SAMUELS, DAVID C · 2007 to 2021
$3.1M
NIGMS NIH HHS T32 GM080178
6 · The paper itself

Abstract

The human capacity to speak is fundamental to our advanced intellectual, technological and social development. Yet so very little is known regarding the evolutionary genetics of speech or its relationship with the broader aspects of evolutionary development in primates. In this study, we describe a large family with evolutionary retrograde development of the larynx and wrist. The family presented with severe speech impairment and incremental retrograde elongations of the pisiform in the wrist that limited wrist rotation from 180° to 90° as in primitive primates. To our surprise, we found that a previously unknown primate-specific gene

Indexed as

Growth Differentiation Factor 6SpeechAnimalsBiological EvolutionHumansMicePrimatesRegulatory Sequences, Nucleic AcidGrowth Differentiation Factor 6bone morphogenetic proteinGDF6gene complexlarynxoverlapping genepisiformprimate evolutionprimate genetranscriptional interferencewrist evolution

Identifiers

PMID35885978
PMCPMC9323761
OpenAlexW4283800175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.