Evidence map›Paper›PMID 35885926›Full record

ArticleGenes2022

Involvement of MicroRNA-27a-3p in the Licorice-Induced Alteration of Cd28 Expression in Mice.

Gang Feng, Guozheng Liang, Yaqian Zhang, Jicong Hu, Chuandong Zhou, Jiawen Li, Wenfeng Zhang, Han Shen, Fenglin Wu, Changli Tao and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Gang FengGuangdong Province Key Laboratory for Biotechnology Drug Candidate, School of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Guozheng LiangGuangdong Province Key Laboratory for Biotechnology Drug Candidate, School of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Yaqian ZhangGuangdong Province Key Laboratory for Biotechnology Drug Candidate, School of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Jicong HuGuangdong Province Key Laboratory for Biotechnology Drug Candidate, School of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Chuandong ZhouGuangdong Province Key Laboratory for Biotechnology Drug Candidate, School of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Jiawen LiGuangdong Province Key Laboratory for Biotechnology Drug Candidate, School of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Wenfeng ZhangGuangdong Province Key Laboratory for Biotechnology Drug Candidate, School of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Han ShenGuangdong Province Key Laboratory for Biotechnology Drug Candidate, School of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Fenglin WuGuangdong Province Key Laboratory for Biotechnology Drug Candidate, School of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Changli TaoGuangdong Province Key Laboratory for Biotechnology Drug Candidate, School of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Yan LiuCollege of Electronic Engineering, South China Agricultural University, Guangzhou 510642, China.
Hongwei ShaoGuangdong Province Key Laboratory for Biotechnology Drug Candidate, School of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Guangdong Pharmaceutical University · CNSouth China Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Licorice has previously been shown to affect gene expression in cells; however, the underlying mechanisms remain to be clarified. We analyzed the microRNA expression profile of serum from mice treated by gavage with licorice decoction, and obtained 11 differentially expressed microRNAs (DEmiRNAs). We also screened differentially expressed genes (DEgenes) based on RNA-Seq data, and 271 common genes were identified by intersection analysis of the predicted target genes of 11 DEmiRNAs and the DEgenes. The miRNA-gene network showed that most of the hub genes were immune-related. KEGG enrichment analysis of the 271 genes identified three significant pathways, and the 21 genes involved in these three pathways, and the 11 DEmiRNAs, were constructed into a miRNA pathway-target gene network, in which

Indexed as

GlycyrrhizaMicroRNAsAnimalsCD28 AntigensGene Regulatory NetworksMiceCD28 AntigensMicroRNAsMirn27 microRNA, mouseCd28gene expressionlicoricemiRNAmmu-miR-27a-3pregulation

Identifiers

PMID35885926
PMCPMC9317804
OpenAlexW4283576255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.