Evidence map›Paper›PMID 35885630›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Natural Language Processing in Diagnostic Texts from Nephropathology.

Maximilian Legnar, Philipp Daumke, Jürgen Hesser, Stefan Porubsky, Zoran Popovic, Jan Niklas Bindzus, Joern-Helge Heinrich Siemoneit, Cleo-Aron Weis

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The association between postoperative physical therapy and opioid prescription after posterior lumbar interbody fusion: a retrospective cohort study of United States academic health centers.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Article
  5. Osteoporosis is not associated with increased reoperation or fracture risk three years after total ankle arthroplasty: a retrospective cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maximilian LegnarMannheim Institute for Intelligent Systems in Medicine (MIISM), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.ORCID 0000-0003-2730-1068
Philipp DaumkeAverbis GmbH, 79098 Freiburg, Germany.
Jürgen HesserInstitute of Pathology, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Stefan PorubskyInstitute of Pathology, Medical Faculty Mainz, University Hospital Mainz, 55131 Mainz, Germany.ORCID 0000-0002-7647-7265
Zoran PopovicInstitute of Pathology, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Jan Niklas BindzusInstitute of Pathology, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Joern-Helge Heinrich SiemoneitInstitute of Pathology, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Cleo-Aron WeisInstitute of Pathology, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.

Funding

German Federal Ministry for Economic Affairs and Climate Action ZIM-grant KK5256201LU1
6 · The paper itself

Abstract

introductionThis study investigates whether it is possible to predict a final diagnosis based on a written nephropathological description-as a surrogate for image analysis-using various NLP methods.

methodsFor this work, 1107 unlabelled nephropathological reports were included. (i) First, after separating each report into its microscopic description and diagnosis section, the diagnosis sections were clustered unsupervised to less than 20 diagnostic groups using different clustering techniques. (ii) Second, different text classification methods were used to predict the diagnostic group based on the microscopic description section.

resultsThe best clustering results (i) could be achieved with HDBSCAN, using BoW-based feature extraction methods. Based on keywords, these clusters can be mapped to certain diagnostic groups. A transformer encoder-based approach as well as an SVM worked best regarding diagnosis prediction based on the histomorphological description (ii). Certain diagnosis groups reached F1-scores of up to 0.892 while others achieved weak classification metrics.

conclusionWhile textual morphological description alone enables retrieving the correct diagnosis for some entities, it does not work sufficiently for other entities. This is in accordance with a previous image analysis study on glomerular change patterns, where some diagnoses are associated with one pattern, but for others, there exists a complex pattern combination.

Indexed as

BERTdeep learningmachine learningnephropathologyNLPtext analysistext classificationtopic modellingtransformer encoder

Identifiers

PMID35885630
PMCPMC9325286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.