ReviewDiagnostics (Basel, Switzerland)2022
The Diagnostic Differentiation Challenge in Acute Appendicitis: How to Distinguish between Uncomplicated and Complicated Appendicitis in Adults.
Review in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Utility of thiol/disulphide homeostasis as a biomarker for acute appendicitis: a systematic review and meta-analysis.Pediatric surgery international · 2024Pooled it
- The role of viruses in human acute appendicitis: a systematic literature review.International journal of colorectal disease · 2023Pooled it
- Associations Between Time-To-Surgery and Postoperative Length of Stay and Complications in Patients With Acute Appendicitis.World journal of surgery · 2026Observational
- A three-dimensional framework for acute appendicitis integrating etiology, pathological severity, and host response.Annals of medicine and surgery (2012) · 2026Article
- Article
- The Role of Emerging Immune-Inflammatory Indexes in the Preoperative Differentiation of Complicated and Uncomplicated Acute Appendicitis: A Single-Center Retrospective Analysis.Diagnostics (Basel, Switzerland) · 2025Article
- Article
- Assessing the Efficacy of Ultrasound Imaging for Diagnosing Appendicitis in Male Patients: A Retrospective Study.Cureus · 2025Article
- A Systematic Integration of Artificial Intelligence Models in Appendicitis Management: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2025Review
- Evaluation of procalcitonin versus conventional inflammatory biomarkers for clinical severity grading in patients with intra-abdominal infection.Langenbeck's archives of surgery · 2025Article
- Discriminatory Value and Validation of a Risk Prediction Model Based on Serum Cytokines in Pediatric Acute Appendicitis: A Single-Center Experience of 483 Cases.Children (Basel, Switzerland) · 2025Article
- Utilizing non-invasive biomarkers for early and accurate differentiation of uncomplicated and complicated acute appendicitis: a retrospective cohort analysis.Scientific reports · 2025Article
- Parasitic appendicitis, what do we know?-a literature review.Translational gastroenterology and hepatology · 2025Review
- Inflammatory Signals Across the Spectrum: A Detailed Exploration of Acute Appendicitis Stages According to EAES 2015 Guidelines.Diagnostics (Basel, Switzerland) · 2024Article
- Internal and external factors affecting the performance score of surgical trainees doing laparoscopic appendectomy: a prospective, observational cohort study in a structured training programme.Surgical endoscopy · 2024Observational
- Risk factors for acute complicated appendicitis in children aged three years and younger.BMC pediatrics · 2024Article
- Treatment of Appendicitis Could Become Even Less Invasive.World journal of surgery · 2023Article
- Article
- Relationship between IgE-mediated allergy and complicated appendicitis in children.Pediatric surgery international · 2023Article
- Eosinophil Granule Proteins Involvement in Acute Appendicitis-An Allergic Disease?International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
(1) Background: How to best define, diagnose and differentiate uncomplicated from complicated acute appendicitis remains debated. Hence, the aim of this review was to present an overview of the current knowledge and emerging field of acute appendicitis with a focus on the diagnostic differentiation of severity currently subject to ongoing investigations. (2) Methods: We conducted a PubMed search using the MeSH terms "appendicitis AND severity" and "appendicitis AND classification", with a focus on studies calling appendicitis as 'uncomplicated' or 'complicated'. An emphasis on the last 5 years was stressed, with further studies selected for their contribution to the theme. Further studies were retrieved from identified full-text articles and included per the authors' discretion. (3) Results: The assumption that appendicitis invariably will proceed to perforation has been outdated. Both uncomplicated and complicated appendicitis exist with likely different pathophysiology. Hence, this makes it important to differentiate disease severity. Clinicians must diagnose appendicitis, but, in the next step, also differentiate between uncomplicated and complicated appendicitis in order to allow for management decisions. Diagnostic accuracy without supportive imaging is around 75-80% and, based on clinical judgement and blood tests alone, the negative appendectomy rate has been described as high as 36%. More research is needed on available biomarkers, and the routine use of imaging still remains debated. Scoring systems have the potential to improve diagnostic accuracy, but no scoring system has yet been validated for differentiating disease severity. Currently, no universally agreed definition exists on what constitutes a complicated appendicitis. (4) Conclusions: Uncomplicated and complicated appendicitis appear to have different pathophysiology and should be treated differently. The differentiation between uncomplicated and complicated appendicitis remains a diagnostic challenge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.