Evidence map›Paper›PMID 35885550›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Gestational Diabetes Melitus and Cord Blood Platelet Function Studied via the PFA-100 System.

Vasiliki Mougiou, Theodora Boutsikou, Rozeta Sokou, Maria Kollia, Serena Valsami, Abraham Pouliakis, Maria Boutsikou, Marianna Politou, Nicoletta Iacovidou, Zoe Iliodromiti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Vasiliki MougiouNeonatal Department, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, Greece.
Theodora BoutsikouNeonatal Department, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, Greece.
Rozeta SokouNeonatal Department, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, Greece.ORCID 0000-0002-9972-8901
Maria KolliaNeonatal Department, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, Greece.
Serena ValsamiHaematology Laboratory-Blood Bank, Aretaieio Hospital, National and Kapodistrian University of Athens, 115 28 Athens, Greece.
Abraham Pouliakis2nd Department of Pathology, "Attikon" University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, Greece.ORCID 0000-0002-0074-3619
Maria BoutsikouNeonatal Department, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, Greece.ORCID 0000-0002-5457-2472
Marianna PolitouHaematology Laboratory-Blood Bank, Aretaieio Hospital, National and Kapodistrian University of Athens, 115 28 Athens, Greece.
Nicoletta IacovidouNeonatal Department, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, Greece.ORCID 0000-0001-8021-6191
Zoe IliodromitiNeonatal Department, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, Greece.ORCID 0000-0003-4316-7305
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal platelet hemostasis, although it has been well described over the recent years, remains elusive in specific patient populations, including neonates from high-risk pregnancies, such as those complicated with gestational diabetes mellitus (GDM). We aimed at evaluating the platelet function of neonates born to mothers with GDM using the platelet function analyzer (PFA-100). Cord blood samples were drawn from each subject and tested with two different agonists to provide two closure time (CT) values (collagen with epinephrine (COL/EPI) and collagen with adenosine diphosphate (COL/ADP)). A total of 84 and 118 neonates formed the GDM and the control group (neonates from uncomplicated pregnancies), respectively. COL/EPI CTs were prolonged in neonates from the GDM group compared to neonates from the control group, while no statistically significant difference of COL/ADP CTs was noted between the two groups, GDM and the control. Higher COL/ADP CTs were demonstrated in neonates born via cesarean section and in neonates with blood group O. A negative correlation between COL/ADP CT and gestational age, white blood cells (WBCs) and von Willebrand factor (VWF) activity was noted in neonates from the GDM group. In conclusion, neonates from the GDM group demonstrate a more hyporesponsive phenotype of their platelets, in comparison to the control neonates.

Indexed as

gestational diabetes mellitusneonatesPFA-100platelet functionprimary hemostasis

Identifiers

PMID35885550
PMCPMC9318840
OpenAlexW4283837450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.