Evidence map›Paper›PMID 35885469›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Gastrointestinal Stromal Tumors Mimicking Gynecologic Disease: Clinicopathological Analysis of 20 Cases.

Ying Liu, Maryam Shahi, Karin Miller, Christian F Meyer, Chien-Fu Hung, T-C Wu, Russell Vang, Deyin Xing

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ying LiuDepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
Maryam ShahiDepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
Karin MillerDepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
Christian F MeyerDepartment of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
Chien-Fu HungDepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
T-C WuDepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
Russell VangDepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
Deyin XingDepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
Johns Hopkins University · USWinnMed · US

Funding

Treatment of HIV- and HIV+ Patients with HPV16+ CIN2/3 Using pNGLV4a-hCRTE6E7L2 DNA vaccine administered intramuscularly via electroporationP50CA098252 · NCI · JOHNS HOPKINS UNIVERSITY · PI TZYY-CHOOU WU · 2003 to 2026
$53.5M
NCI NIH HHS P50 CA098252
6 · The paper itself

Abstract

Diagnosis of pelvic gastrointestinal stromal tumors (GISTs) can be challenging because of their nonspecific presentation and similarity to gynecological neoplasms. In this series, we describe the clinicopathological features of 20 GIST cases: 18 patients presented with pelvic mass and/or abdominal pain concerning gynecological disease; 2 patients presented with a posterior rectovaginal mass or an anorectal mass. Total abdominal hysterectomy and/or salpingo-oophorectomy (unilateral or bilateral) were performed in 13 cases. Gross and histological examination revealed that the ovary/ovaries were involved in three cases, the uterus in two cases, the vagina in two cases and the broad ligament in one case. Immunohistochemically, all tumors (20/20, 100%) were diffusely immunoreactive for c-KIT. The tumor cells were also diffusely positive for DOG-1 (10/10, 100%) and displayed focal to diffuse positivity for CD34 (11/12, 92%). Desmin was focally and weakly expressed in 1 of the 14 tested tumors (1/14, 7%), whereas 2 of 8 tumors (2/8, 25%) showed focal SMA positivity. At the molecular level, 7 of 8 (87.5%) GISTs with molecular analysis contained

Indexed as

c-KITFGFR3gastrointestinal stromal tumorpelvic massRB1

Identifiers

PMID35885469
PMCPMC9319443
OpenAlexW4283646832

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.