Evidence map›Paper›PMID 35885455›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Transformers Improve Breast Cancer Diagnosis from Unregistered Multi-View Mammograms.

Xuxin Chen, Ke Zhang, Neman Abdoli, Patrik W Gilley, Ximin Wang, Hong Liu, Bin Zheng, Yuchen Qiu

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Assessment of transformer-based AI in clinical oncology.BMC medical informatics and decision making · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xuxin ChenSchool of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019, USA.ORCID 0000-0001-8872-8992
Ke ZhangSchool of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019, USA.ORCID 0000-0003-3194-2546
Neman AbdoliSchool of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019, USA.
Patrik W GilleySchool of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019, USA.
Ximin WangXPeng Motors, Guangzhou 510640, China.
Hong LiuSchool of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019, USA.
Bin ZhengSchool of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019, USA.ORCID 0000-0002-7682-6648
Yuchen QiuSchool of Electrical and Computer Engineering, University of Oklahoma, Norman, OK 73019, USA.

Funding

Use of 3D Quantitative Optical Methods to Optimize Mebendazole Treatment of Ovarian CancerP20GM135009 · NIGMS · UNIVERSITY OF OKLAHOMA · PI Yuye Ling · 2022 to 2026
$13.6M
NIGMS NIH HHS P20 GM135009NIH HHS P20 GM135009
6 · The paper itself

Abstract

Deep convolutional neural networks (CNNs) have been widely used in various medical imaging tasks. However, due to the intrinsic locality of convolution operations, CNNs generally cannot model long-range dependencies well, which are important for accurately identifying or mapping corresponding breast lesion features computed from unregistered multiple mammograms. This motivated us to leverage the architecture of Multi-view Vision Transformers to capture long-range relationships of multiple mammograms from the same patient in one examination. For this purpose, we employed local transformer blocks to separately learn patch relationships within four mammograms acquired from two-view (CC/MLO) of two-side (right/left) breasts. The outputs from different views and sides were concatenated and fed into global transformer blocks, to jointly learn patch relationships between four images representing two different views of the left and right breasts. To evaluate the proposed model, we retrospectively assembled a dataset involving 949 sets of mammograms, which included 470 malignant cases and 479 normal or benign cases. We trained and evaluated the model using a five-fold cross-validation method. Without any arduous preprocessing steps (e.g., optimal window cropping, chest wall or pectoral muscle removal, two-view image registration, etc.), our four-image (two-view-two-side) transformer-based model achieves case classification performance with an area under ROC curve (AUC = 0.818 ± 0.039), which significantly outperforms AUC = 0.784 ± 0.016 achieved by the state-of-the-art multi-view CNNs (

Indexed as

breast cancerclassificationcomputer-aided diagnosisdeep learningmammogrammulti-viewself-attentiontransformer

Identifiers

PMID35885455
PMCPMC9320758

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.