Evidence map›Paper›PMID 35885421›Full record

ReviewDiagnostics (Basel, Switzerland)2022

Association of Prognostic Nutritional Index with Severity and Mortality of Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis.

Kuo-Chuan Hung, Ching-Chung Ko, Li-Kai Wang, Ping-Hsin Liu, I-Wen Chen, Yen-Ta Huang, Cheuk-Kwan Sun

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kuo-Chuan HungDepartment of Anesthesiology, Chi Mei Medical Center, Tainan City 71004, Taiwan.ORCID 0000-0002-4507-8085
Ching-Chung KoDepartment of Medical Imaging, Chi Mei Medical Center, Tainan City 71004, Taiwan.ORCID 0000-0003-0721-9606
Li-Kai WangDepartment of Anesthesiology, Chi Mei Medical Center, Tainan City 71004, Taiwan.ORCID 0000-0001-8640-8231
Ping-Hsin LiuDepartment of Anesthesiology, E-Da Hospital, Kaohsiung City 82445, Taiwan.ORCID 0000-0001-7208-4627
I-Wen ChenDepartment of Anesthesiology, Chi Mei Hospital, Liouying, Tainan City 710402, Taiwan.ORCID 0000-0003-0750-0035
Yen-Ta HuangDepartment of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan City 70101, Taiwan.ORCID 0000-0002-0884-9098
Cheuk-Kwan SunDepartment of Emergency Medicine, E-Da Hospital, Kaohsiung City 82445, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The associations of prognostic nutritional index (PNI) with disease severity and mortality in patients with coronavirus disease 2019 (COVID-19) remain unclear. Electronic databases, including MEDLINE, EMBASE, Google scholar, and Cochrane Library, were searched from inception to 10 May 2022. The associations of PNI with risk of mortality (primary outcome) and disease severity (secondary outcome) were investigated. Merged results from meta-analysis of 13 retrospective studies (4204 patients) published between 2020 and 2022 revealed a lower PNI among patients in the mortality group [mean difference (MD): −8.65, p < 0.001] or severity group (MD: −5.19, p < 0.001) compared to those in the non-mortality or non-severity groups. A per-point increase in PNI was associated with a reduced risk of mortality [odds ratio (OR) = 0.84, 95% CI: 0.79 to 0.9, p < 0.001, I2 = 67.3%, seven studies] and disease severity (OR = 0.84, 95% CI: 0.77 to 0.92, p < 0.001, I2 = 83%, five studies). The pooled diagnostic analysis of mortality yielded a sensitivity of 0.76, specificity of 0.71, and area under curve (AUC) of 0.79. Regarding the prediction of disease severity, the sensitivity, specificity, and AUC were 0.8, 0.61, and 0.65, respectively. In conclusion, this study demonstrated a negative association between PNI and prognosis of COVID-19. Further large-scale trials are warranted to support our findings.

Indexed as

area under curvecoronavirus disease 2019disease severitymortalityprognostic nutritional index

Identifiers

PMID35885421
PMCPMC9322949

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.