Evidence map›Paper›PMID 35884952›Full record

ArticleBiomedicines2022

β-Adrenergic Receptor Stimulation Maintains NCX-CaMKII Axis and Prevents Overactivation of

Ingrid Matzer, Julia Voglhuber, Mara Kiessling, Nataša Djalinac, Viktoria Trummer-Herbst, Nishani Mabotuwana, Lavinia Rech, Michael Holzer, Samuel Sossalla, Peter P Rainer and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Autonomic dysregulation and atrial arrhythmias.American journal of physiology. Cell physiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 3 countries.

Ingrid MatzerDepartment of Cardiology, Medical University of Graz, 8036 Graz, Austria.
Julia VoglhuberDepartment of Cardiology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0003-0102-7902
Mara KiesslingDepartment of Cardiology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0001-5626-2227
Nataša DjalinacDepartment of Cardiology, Medical University of Graz, 8036 Graz, Austria.
Viktoria Trummer-HerbstDepartment of Cardiology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-0079-239X
Nishani MabotuwanaDepartment of Cardiology, Medical University of Graz, 8036 Graz, Austria.
Lavinia RechDepartment of Cardiology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-0787-446X
Michael HolzerBioTechMed-Graz, 8010 Graz, Austria.
Samuel SossallaDepartment of Internal Medicine II, University Medical Centre Regensburg, 93053 Regensburg, Germany.ORCID 0000-0001-8034-2673
Peter P RainerDepartment of Cardiology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0002-2840-6454
Andreas ZirlikDepartment of Cardiology, Medical University of Graz, 8036 Graz, Austria.
Senka Ljubojevic-HolzerDepartment of Cardiology, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0001-6994-9976
Medical University of Graz · ATUniversity Hospital Regensburg · DE

Funding

BioTechMed-Graz Young Researcher Groups (YRG)FWF Austrian Science Fund AIR-MI (I 4168-B)FWF Austrian Science Fund V-530
6 · The paper itself

Abstract

Excessive β-adrenergic stimulation and tachycardia are potent triggers of cardiac remodeling; however, their exact cellular effects remain elusive. Here, we sought to determine the potency of β-adrenergic stimulation and tachycardia to modulate gene expression profiles of cardiomyocytes. Using

Indexed as

CaMKIIcardiomyocytehypertensive cardiomyopathyhypertrophyIL6Risoprenalineβ-adrenergic signaling

Identifiers

PMID35884952
PMCPMC9313457
OpenAlexW4284964342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.