Evidence map›Paper›PMID 35884934›Full record

ArticleBiomedicines2022

Diagnostic Cerebrospinal Fluid Biomarker in Early and Late Onset Multiple Sclerosis.

Franz Felix Konen, Malte Johannes Hannich, Philipp Schwenkenbecher, Matthias Grothe, Konrad Gag, Konstantin Fritz Jendretzky, Stefan Gingele, Kurt-Wolfram Sühs, Torsten Witte, Thomas Skripuletz and 1 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07183020 (Prospective, Multicentric, Real-world Investigation of Kappa Free Light Chains), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07183020 enrolling by invitationnot on this map

Prospective, Multicentric, Real-world Investigation of Kappa Free Light Chains (KFLC) in Multiple Sclerosis (MS) and Clinically Isolated Syndrome (CIS)

TypeobservationalSponsorSkripuletz, Thomas Prof. Dr.Ran2022 to 2026Enrolled1,142ConditionsMultiple Sclerosis, Clinically Isolated Syndrome (CIS)ArmsOligoclonal bands and kappa free light chains (KFLC)
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Observational
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Franz Felix KonenDepartment of Neurology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-8609-5674
Malte Johannes HannichInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0000-0002-6783-7468
Philipp SchwenkenbecherDepartment of Neurology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-1260-1650
Matthias GrotheDepartment of Neurology, University Medicine Greifswald, 17475 Greifswald, Germany.
Konrad GagDepartment of Neurology, University Medicine Greifswald, 17475 Greifswald, Germany.ORCID 0000-0001-9867-0739
Konstantin Fritz JendretzkyDepartment of Neurology, Hannover Medical School, 30625 Hannover, Germany.
Stefan GingeleDepartment of Neurology, Hannover Medical School, 30625 Hannover, Germany.
Kurt-Wolfram SühsDepartment of Neurology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-8077-481X
Torsten WitteDepartment of Rheumatology & Immunology, Hannover Medical School, 30625 Hannover, Germany.
Thomas SkripuletzDepartment of Neurology, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0001-8550-335X
Marie SüßeDepartment of Neurology, University Medicine Greifswald, 17475 Greifswald, Germany.
Medizinische Hochschule Hannover · DEUniversitätsmedizin Greifswald · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cerebrospinal fluidearly onset MSfree light chains kappahumoral immune responseimmunoglobulinslate onset MSMRZ reactionmultiple sclerosisoligoclonal bandsprogressive MS

Identifiers

PMID35884934
PMCPMC9312908
OpenAlexW4284714139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.