Evidence map›Paper›PMID 35884770›Full record

ReviewBiomedicines2022

Immune Response to SARS-CoV-2 Vaccines.

Navya Bellamkonda, Upendra Pradeep Lambe, Sonali Sawant, Shyam Sundar Nandi, Chiranjib Chakraborty, Deepak Shukla

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trust in Transition: Exploring Changing Trust in Vaccination in the Context of Long Covid in the United Kingdom.Health expectations : an international journal of public participation in health care and health policy · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Navya BellamkondaDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-0167-3111
Upendra Pradeep LambeICMR-NIV, Mumbai Unit, A. D. Road, Parel, Mumbai 400012, India.
Sonali SawantICMR-NIV, Mumbai Unit, A. D. Road, Parel, Mumbai 400012, India.
Shyam Sundar NandiICMR-NIV, Mumbai Unit, A. D. Road, Parel, Mumbai 400012, India.
Chiranjib ChakrabortySchool of Life Science and Biotechnology, Adamas University, Kolkata 700126, India.ORCID 0000-0002-3958-239X
Deepak ShuklaDepartment of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-3039-6953
ICMR-National Institute of Virology · INUniversity of Illinois Chicago · USAdamas University · IN

Funding

A new molecular therapy against ocular herpesR01EY024710 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DEEPAK SHUKLA · 2015 to 2026
$5.2M
A small molecule inhibitor of HSV genital infectionsR01AI139768 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SHUKLA, DEEPAK · 2018 to 2021
$1.6M
NIAID NIH HHS R01 AI139768NIH HHS EY024710
6 · The paper itself

Abstract

COVID-19 vaccines have been developed to confer immunity against the SARS-CoV-2 infection. Prior to the pandemic of COVID-19 which started in March 2020, there was a well-established understanding about the structure and pathogenesis of previously known Coronaviruses from the SARS and MERS outbreaks. In addition to this, vaccines for various Coronaviruses were available for veterinary use. This knowledge supported the creation of various vaccine platforms for SARS-CoV-2. Before COVID-19 there are no reports of a vaccine being developed in under a year and no vaccine for preventing coronavirus infection in humans had ever been developed. Approximately nine different technologies are being researched and developed at various levels in order to design an effective COVID-19 vaccine. As the spike protein of SARS-CoV-2 is responsible for generating substantial adaptive immune response, mostly all the vaccine candidates have been targeting the whole spike protein or epitopes of spike protein as a vaccine candidate. In this review, we have compiled the immune response to SARS-CoV-2 infection and followed by the mechanism of action of various vaccine platforms such as mRNA vaccines, Adenoviral vectored vaccine, inactivated virus vaccines and subunit vaccines in the market. In the end we have also summarized the various adjuvants used in the COVID-19 vaccine formulation.

Indexed as

adenoviral vectored vaccineadjuvantsCOVID-19inactivated vaccinemRNA vaccineSARS-CoV-2subunit vaccine

Identifiers

PMID35884770
PMCPMC9312515
OpenAlexW4283259134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.