Evidence map›Paper›PMID 35884768›Full record

ArticleBiomedicines2022

Risk of Malignancy in Patients with Asthma-COPD Overlap Compared to Patients with COPD without Asthma.

Barbara Bonnesen, Pradeesh Sivapalan, Alexander Jordan, Johannes Wirenfeldt Pedersen, Christina Marisa Bergsøe, Josefin Eklöf, Louise Lindhardt Toennesen, Sidse Graff Jensen, Matiullah Naqibullah, Zaigham Saghir and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07476404 (Re-bleeding in Giant Meningioma and Intraoperative Hydroxyethyl Starch), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07476404 completednot on this mapstarted 2025, after this paper: background citation

Re-bleeding in Giant Meningioma and Intraoperative Hydroxyethyl Starch (HES) Fluid Therapy: A Retrospective Cohort Study

Typeobservational_patient_registrySponsorChiang Mai UniversityRan2025 to 2026Enrolled300ConditionsMeningioma of Brain, Meningioma SurgeryArmsexposure to Hydroxyethyl Starch (HES) Voluven® or Volulyte® 130/0.4
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Barbara BonnesenSection of Respiratory Medicine, Department of Medicine, Herlev and Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.
Pradeesh SivapalanSection of Respiratory Medicine, Department of Medicine, Herlev and Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.
Alexander JordanSection of Respiratory Medicine, Department of Medicine, Herlev and Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.
Johannes Wirenfeldt PedersenDepartment of Oncology, Herlev and Gentofte Hospital, University of Copenhagen, 2730 Herlev, Denmark.
Christina Marisa BergsøeSection of Respiratory Medicine, Department of Medicine, Herlev and Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.ORCID 0000-0001-7144-0108
Josefin EklöfSection of Respiratory Medicine, Department of Medicine, Herlev and Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.
Louise Lindhardt ToennesenDepartment of Respiratory Medicine, University of Copenhagen, Hvidovre Hospital, 2650 Hvidovre, Denmark.
Sidse Graff JensenSection of Respiratory Medicine, Department of Medicine, Herlev and Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.
Matiullah NaqibullahSection of Respiratory Medicine, Department of Medicine, Herlev and Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.
Zaigham SaghirSection of Respiratory Medicine, Department of Medicine, Herlev and Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.
Jens-Ulrik Stæhr JensenSection of Respiratory Medicine, Department of Medicine, Herlev and Gentofte Hospital, University of Copenhagen, 2900 Hellerup, Denmark.ORCID 0000-0003-4036-0521
University of Copenhagen · DK

Funding

Novo Nordisk Foundation NNF20OC0060657
6 · The paper itself

Abstract

Chronic inflammation such as asthma may lead to higher risks of malignancy, which may be inhibited by anti-inflammatory medicine such as inhaled corticosteroids (ICS). The aim of this study was to evaluate if patients with asthma-Chronic Obstructive Pulmonary Disease (COPD) overlap have a higher risk of malignancy than patients with COPD without asthma, and, secondarily, if inhaled corticosteroids modify such a risk in a nationwide multi-center retrospective cohort study of Danish COPD-outpatients with or without asthma. Patients with asthma-COPD overlap were propensity score matched (PSM) 1:2 to patients with COPD without asthma. The endpoint was cancer diagnosis within 2 years. Patients were stratified depending on prior malignancy within 5 years. ICS was explored as a possible risk modifier. We included 50,897 outpatients with COPD; 88% without prior malignancy and 20% with asthma. In the PSM cohorts, 26,003 patients without prior malignancy and 3331 patients with prior malignancy were analyzed. There was no association between asthma-COPD overlap and cancer with hazard ratio (HR) = 0.92, CI = 0.78-1.08,

Indexed as

asthmaasthma-COPD overlapcancerChronic Obstructive Pulmonary Disease (COPD)ICSinhaled corticosteroids

Identifiers

PMID35884768
PMCPMC9313308
OpenAlexW4283261294

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.