Evidence map›Paper›PMID 35884755›Full record

ReviewBrain sciences2022

Magnetic Resonance Planimetry in the Differential Diagnosis between Parkinson's Disease and Progressive Supranuclear Palsy.

Andrea Quattrone, Maurizio Morelli, Maria G Bianco, Jolanda Buonocore, Alessia Sarica, Maria Eugenia Caligiuri, Federica Aracri, Camilla Calomino, Marida De Maria, Maria Grazia Vaccaro and 4 more

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07667478 (NON-INVASIVE BRAIN STIMULATION FOR MEMORY LOSS IN EARLY ALZHEIMER'S DISEASE), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07667478 narecruitingnot on this mapstarted 2026, after this paper: background citation

Non-invasive brain stimulation for memory loss in early alzheimer's disease

TypeinterventionalSponsorChi-Ying (Roy) LinRan2026 to 2031Enrolled40ConditionsAlzheimer s Disease, Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, Mild DementiaArmsrepetitive transcranial magnetic stimulation (rTMS), sham repetitive transcranial magnetic stimulation rTMS
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. A Brainstem Radiomics Framework to Distinguish Progressive Supranuclear Palsy from Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  2. Article
  3. Article
  4. Deep Learning Framework for Automated MRI Planimetry in Multiple Sclerosis.International journal of biomedical imaging · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Andrea QuattroneInstitute of Neurology, University "Magna Graecia", 88100 Catanzaro, Italy.
Maurizio MorelliInstitute of Neurology, University "Magna Graecia", 88100 Catanzaro, Italy.
Maria G BiancoDepartment of Medical and Surgical Sciences, University "Magna Graecia", 88100 Catanzaro, Italy.ORCID 0000-0002-2705-8718
Jolanda BuonocoreInstitute of Neurology, University "Magna Graecia", 88100 Catanzaro, Italy.
Alessia SaricaNeuroscience Research Center, University "Magna Graecia", 88100 Catanzaro, Italy.
Maria Eugenia CaligiuriNeuroscience Research Center, University "Magna Graecia", 88100 Catanzaro, Italy.ORCID 0000-0002-2030-5552
Federica AracriNeuroscience Research Center, University "Magna Graecia", 88100 Catanzaro, Italy.
Camilla CalominoNeuroscience Research Center, University "Magna Graecia", 88100 Catanzaro, Italy.
Marida De MariaNeuroscience Research Center, University "Magna Graecia", 88100 Catanzaro, Italy.
Maria Grazia VaccaroNeuroscience Research Center, University "Magna Graecia", 88100 Catanzaro, Italy.ORCID 0000-0001-8666-0461
Vera GramignaNeuroscience Research Center, University "Magna Graecia", 88100 Catanzaro, Italy.
Antonio AugimeriBiotecnomed S.C.aR.L., 88100 Catanzaro, Italy.
Basilio VescioInstitute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), 88100 Catanzaro, Italy.
Aldo QuattroneNeuroscience Research Center, University "Magna Graecia", 88100 Catanzaro, Italy.
Magna Graecia University · ITInstitute of Molecular Bioimaging and Physiology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical differential diagnosis between Parkinson's disease (PD) and progressive supranuclear palsy (PSP) is often challenging. The description of milder PSP phenotypes strongly resembling PD, such as PSP-Parkinsonism, further increased the diagnostic challenge and the need for reliable neuroimaging biomarkers to enhance the diagnostic certainty. This review aims to summarize the contribution of a relatively simple and widely available imaging technique such as MR planimetry in the differential diagnosis between PD and PSP, focusing on the recent advancements in this field. The development of accurate MR planimetric biomarkers, together with the implementation of automated algorithms, led to robust and objective measures for the differential diagnosis of PSP and PD at the individual level. Evidence from longitudinal studies also suggests a role of MR planimetry in predicting the development of the PSP clinical signs, allowing to identify PSP patients before they meet diagnostic criteria when their clinical phenotype can be indistinguishable from PD. Finally, promising evidence exists on the possible association between MR planimetric measures and the underlying pathology, with important implications for trials with new disease-modifying target therapies.

Indexed as

biomarkersMRPIMR planimetryParkinson’s diseaseprogressive supranuclear palsy

Identifiers

PMID35884755
PMCPMC9313181
OpenAlexW4286005793

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.