ReviewBrain sciences2022
The Patent Foramen Ovale and Migraine: Associated Mechanisms and Perspectives from MRI Evidence.
Review in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 36 citations in OpenAlex.
- Trial
- Observational
- The relationship between anxiety and patent foramen ovale: a preliminary study.BMC psychology · 2026Observational
- Quantitative assessment and clinical value of right-to-left shunt in patent foramen ovale using three-dimensional transesophageal echocardiography combined with right-heart contrast: a prospective study.Cardiovascular diagnosis and therapy · 2026Article
- Patent Foramen Ovale on Transthoracic Echocardiography and Brain White-Matter Hyperintensities: A Transportability Analysis and Practice-Anchored Risk Framework.Journal of clinical medicine · 2026Article
- Artificial intelligence in migraine: a narrative review on the diagnostic, prognostic, and therapeutic applications.Oxford open neuroscience · 2026Article
- Migraine and patent foramen ovale: correlation, coexistence, dependence. A narrative review.Headache · 2026Review
- Experimental Study of the TAI QINGActa Cardiologica Sinica · 2025Article
- Article
- Artificial Intelligence in the Diagnostic Use of Transcranial Doppler and Sonography: A Scoping Review of Current Applications and Future Directions.Bioengineering (Basel, Switzerland) · 2025Review
- Right Heart Contrast Echocardiography Microbubble Count and Migraine Severity: A Dose-Effect Relationship Study.Clinical cardiology · 2025Article
- Clinical characteristics and short-term outcomes of migraine with patent foramen ovale: a comparative study.European journal of medical research · 2025Article
- Navigating the Diagnostic Maze: A Case Report and Narrative Review of Reversible Cerebral Vasoconstriction SyndromeCurrent medical imaging · 2025Review
- Advances in the Study of the Correlation Between Patent Foramen Ovale and Migraine.Psychiatry and clinical psychopharmacology · 2024Article
- Comparison of the Application Value of Transthoracic Echocardiography in Diagnosing Patent Foramen Ovale Under Different States of Stimulation: A Retrospective Study.Clinical cardiology · 2024Article
- Contrast-enhanced transcranial Doppler for the detection of right-to-left shunt: A new provocation method with a syringe-modified Valsalva maneuver.Brain and behavior · 2024Article
- Calcitonin gene-related peptide: a possible biomarker in migraine patients with patent foramen ovale.BMC neurology · 2024Article
- A three-classification model for identifying migraine with right-to-left shunt using lateralization of functional connectivity and brain network topology: a resting-state fMRI study.Frontiers in neuroscience · 2024Article
- Right-to-left shunt-associated brain functional changes in migraine: evidences from a resting-state FMRI study.Frontiers in human neuroscience · 2024Article
- Migraine and heart: A reality check.Global cardiology science & practice · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Migraine is a common neurological disease with a still-unclear etiology and pathogenesis. Patent foramen ovale (PFO) is a kind of congenital heart disease that leads to a right-to-left shunt (RLS). Although previous studies have shown that PFO has an effect on migraine, a clear conclusion about the link between PFO and migraine is lacking. We first summarized the PFO potential mechanisms associated with migraine, including microembolus-triggered cortical spreading depression (CSD), the vasoactive substance hypothesis, impaired cerebral autoregulation (CA), and a common genetic basis. Further, we analyzed the changes in brain structure and function in migraine patients and migraine patients with PFO. We found that in migraine patients with PFO, the presence of PFO may affect the structure of the cerebral cortex and the integrity of white matter, which is mainly locked in subcortical, deep white matter, and posterior circulation, and may lead to changes in brain function, such as cerebellum and colliculus, which are involved in the processing and transmission of pain. In summary, this paper provides neuroimaging evidence and new insights into the correlation between PFO and migraine, which will help to clarify the etiology and pathogenesis of migraine, and aid in the diagnosis and treatment of migraine in the future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.