ArticleBrain sciences2022
Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study
Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Pooled it
- Low-Level Alcohol Consumption in Children 11-12 Years Old Is Linked to Neural Substrates Involved in Reward Processing and Inhibitory Control: Results From a Brain-Wide Association Study.Alcohol, clinical & experimental research · 2026Article
- Familial risk factors required to predict earlier adolescent substance use in youth with externalizing disorders.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026Article
- Intertemporal Decision-Making, Nucleus Accumbens Activation, and Alcohol Use Trajectories in Young Adults With a Family History of Alcohol Use Disorder.Alcohol, clinical & experimental research · 2026Article
- Blunted reward-related striatal activity and behavioral disinhibition as a pathway to adolescent cannabis and e-cigarette use.Frontiers in adolescent medicine · 2026Article
- Delay Discounting, Nucleus Accumbens Activation, and Alcohol Use Trajectories in Young Adults with a Family History of Alcohol Use Disorder.medRxiv : the preprint server for health sciences · 2025Article
- Parental substance use history density and its influence on reward anticipation brain activation in late childhood and early adolescence.Developmental cognitive neuroscience · 2025Article
- Parental Alcohol Use Predicts Neural Emotion Reactivity and Substance Use Intentions in Early Adolescence.The Journal of early adolescence · 2025Article
- The ABCD and HBCD Studies: Longitudinal Studies to Inform Prevention Science.Focus (American Psychiatric Publishing) · 2024Review
- Neural responses to reward, threat, and emotion regulation and transition to hazardous alcohol use.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Article
- Synaptic pruning during adolescence shapes adult social behavior in both males and females.Developmental psychobiology · 2024Article
- Neural response to threat and reward among young adults at risk for alcohol use disorder.Addiction biology · 2024Article
- NEURAL RESPONSE TO THREAT AND REWARD AMONG YOUNG ADULTS AT RISK FOR ALCOHOL USE DISORDER.medRxiv : the preprint server for health sciences · 2023Article
- Differences in parent and youth perceived neighborhood threat on nucleus accumbens-frontoparietal network resting state connectivity and alcohol sipping in children enrolled in the ABCD study.Frontiers in psychiatry · 2023Article
- Postnatal environment differentially modulates neurodevelopmental outcomes following voluntary prenatal oxycodone exposure in rats.Neurotoxicology and teratologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Having a family history of alcohol use problems (FH+) conveys risk for alcohol use in offspring. Reward-related brain functioning may play a role in this vulnerability. The present study investigated brain function in the nucleus accumbens (NAcc) associated with the anticipation of reward in youth with two biological parents with alcohol use problems (FH+2), one biological parent with alcohol use problems (FH+1), and no biological parents with alcohol use problems (FH-). Participants were from the large, national Adolescent Brain Cognitive Development (ABCD) Study (mean age: 9.93; 48% female; FH+2 n = 223, FH+1 n = 1447, FH- n = 9690) and the Michigan Longitudinal Study (MLS), consisting of community-recruited families with high rates of alcohol use disorder (mean age: 10.54; 39.3% female; FH+2 n = 40, FH+1 n = 51, FH- n = 40). Reward anticipation was measured by the monetary incentive delay task. Regression models were used to assess associations between FH status and the anticipation of large rewards in right and left NAcc regions of interest. In both studies, FH+2 youth showed blunted anticipatory reward responding in the right NAcc compared to FH+1 youth. In the MLS, FH+2 youth also had blunted anticipatory reward responding in the right NAcc compared to the FH- group. Convergent results across two separate samples provide insights into a unique vulnerability of FH+2 youth and suggest that binary FH+ versus FH- categorizations may obscure important differences within FH+ youth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.