Evidence map›Paper›PMID 35884698›Full record

ArticleBrain sciences2022

Validation of the Glasgow Antipsychotic Side-Effect Scale (GASS) in an Italian Sample of Patients with Stable Schizophrenia and Bipolar Spectrum Disorders.

Alessandro Rodolico, Carmen Concerto, Alessia Ciancio, Spyridon Siafis, Laura Fusar-Poli, Carla Benedicta Romano, Elisa Vita Scavo, Antonino Petralia, Salvatore Salomone, Maria Salvina Signorelli and 2 more

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Alessandro RodolicoDepartment of Clinical and Experimental Medicine, Institute of Psychiatry, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-2196-0601
Carmen ConcertoDepartment of Clinical and Experimental Medicine, Institute of Psychiatry, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-7426-5250
Alessia CiancioDepartment of Clinical and Experimental Medicine, Institute of Psychiatry, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-2327-7080
Spyridon SiafisDepartment of Psychiatry and Psychotherapy, School of Medicine, Technical University of Munich, 81675 Munich, Germany.ORCID 0000-0001-8264-2039
Laura Fusar-PoliDepartment of Clinical and Experimental Medicine, Institute of Psychiatry, University of Catania, 95123 Catania, Italy.
Carla Benedicta RomanoDepartment of Clinical and Experimental Medicine, Institute of Psychiatry, University of Catania, 95123 Catania, Italy.
Elisa Vita ScavoDepartment of Clinical and Experimental Medicine, Institute of Psychiatry, University of Catania, 95123 Catania, Italy.
Antonino PetraliaDepartment of Clinical and Experimental Medicine, Institute of Psychiatry, University of Catania, 95123 Catania, Italy.
Salvatore SalomoneDepartment of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 94123 Catania, Italy.ORCID 0000-0001-5307-6103
Maria Salvina SignorelliDepartment of Clinical and Experimental Medicine, Institute of Psychiatry, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-6941-9454
Stefan LeuchtDepartment of Psychiatry and Psychotherapy, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
Eugenio AgugliaDepartment of Clinical and Experimental Medicine, Institute of Psychiatry, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-2146-7737
University of Catania · ITTechnical University of Munich · DE

Funding

POC Sicilia 2014-20 - Avviso 37/2020 G67C20000210002
6 · The paper itself

Abstract

Antipsychotics are a class of psychotropic drugs that improve psychotic symptoms and reduce relapse risk. However, they may cause side effects (SE) that impact patients' quality of life and psychosocial functioning. Therefore, there is a need for practical tools to identify them and possibly intervene. The objective of the present study was to translate into Italian the Glasgow Antipsychotic Side Effect Scale (GASS), which is suggested as the questionnaire of choice to collect SE reported by patients treated with antipsychotics. We administered the GASS and the Udvalg for Kliniske Undersøgelser (UKU) SE scale-which is considered the gold standard-to 100 stable patients with schizophrenia and bipolar spectrum disorders. We measured the structural validity, internal consistency, concurrent criterion validity, construct validity, and clinical feasibility. GASS was characterized by modest structural validity and good internal consistency. The binary correlations concerning the presence of specific symptoms investigated with the GASS and the UKU were strong or relatively strong for only half of them. The GASS total scale score was inversely related to patients' quality of life and psychosocial functioning. The GASS is useful to briefly assess the burden of antipsychotic SE (~5 min) but is not optimal in identifying them.

Indexed as

antipsychoticsbipolar disorderfunctioningquality of lifescaleschizophreniasensitivityside-effectsspecificityvalidation

Identifiers

PMID35884698
PMCPMC9313430
OpenAlexW4284879073

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.