Evidence map›Paper›PMID 35884575›Full record

ArticleCancers2022

Mutational Signature and Integrative Genomic Analysis of Human Papillomavirus-Associated Penile Squamous Cell Carcinomas from Latin American Patients.

Luisa Matos Canto, Jenilson Mota da Silva, Patrícia Valèria Castelo-Branco, Ingrid Monteiro da Silva, Leudivan Nogueira, Carlos Eduardo Fonseca-Alves, André Khayat, Alexander Birbrair, Silma Regina Pereira

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Luisa Matos CantoClinical Genetics Department, University Hospital of Southern Denmark, 7100 Vejle, Denmark.ORCID 0000-0001-9095-9431
Jenilson Mota da SilvaPostgraduate Program in Health Science, Federal University of Maranhão, São Luís 65080-805, MA, Brazil.
Patrícia Valèria Castelo-BrancoLaboratory of Genetics and Molecular Biology, Department of Biology, Federal University of Maranhão, São Luís 65080-805, MA, Brazil.
Ingrid Monteiro da SilvaLaboratory of Genetics and Molecular Biology, Department of Biology, Federal University of Maranhão, São Luís 65080-805, MA, Brazil.
Leudivan NogueiraAldenora Bello Cancer Hospital, São Luís 65031-630, MA, Brazil.
Carlos Eduardo Fonseca-AlvesHealth Science Institute, Paulista University, Bauru 186085-500, SP, Brazil.ORCID 0000-0002-6702-6139
André KhayatOncology Research Center, Federal University of Pará, Belém 66073-005, PA, Brazil.
Alexander BirbrairDepartment of Dermatology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0003-1015-2561
Silma Regina PereiraLaboratory of Genetics and Molecular Biology, Department of Biology, Federal University of Maranhão, São Luís 65080-805, MA, Brazil.
Universidade Federal do Maranhão · BRUniversidade Federal de Minas Gerais · BRUniversidade Federal do Pará · BRUniversidade Paulista · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior CODE 001Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão COOPI-07895/17; IECT-05551/18; POSGRAD 02598/21
6 · The paper itself

Abstract

High-throughput DNA sequencing has allowed for the identification of genomic alterations and their impact on tumor development, progression, and therapeutic responses. In PSCC, for which the incidence has progressively increased worldwide, there are still limited data on the molecular mechanisms involved in the disease pathogenesis. In this study, we characterized the mutational signature of 30 human papillomavirus (HPV)-associated PSCC cases from Latin Americans, using whole-exome sequencing. Copy number variations (CNVs) were also identified and compared to previous array-generated data. Enrichment analyses were performed to reveal disrupted pathways and to identify alterations mapped to HPV integration sites (HPVis) and miRNA-mRNA hybridization regions. Among the most frequently mutated genes were

Indexed as

biomarkerscarcinomaHPVpeniswhole-exome sequencing

Identifiers

PMID35884575
PMCPMC9316960
OpenAlexW4285891628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.