Evidence map›Paper›PMID 35884462›Full record

ReviewCancers2022

Advanced Neuroimaging Approaches to Pediatric Brain Tumors.

Rahul M Nikam, Xuyi Yue, Gurcharanjeet Kaur, Vinay Kandula, Abdulhafeez Khair, Heidi H Kecskemethy, Lauren W Averill, Sigrid A Langhans

Abstract readReview
In one paragraph

Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. The emerging role of intraoperative nanopore sequencing on the neurosurgical strategy in paediatric embryonal brain tumours.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
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  19. Review
  20. Advances in the Treatment of Pediatric Brain Tumors.Children (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rahul M NikamDepartment of Radiology, Nemours Children's Hospital, Delaware, Wilmington, DE 19803, USA.
Xuyi YueDepartment of Radiology, Nemours Children's Hospital, Delaware, Wilmington, DE 19803, USA.
Gurcharanjeet KaurDepartment of Neurology, Nemours Children's Hospital, Delaware, Wilmington, DE 19803, USA.
Vinay KandulaDepartment of Radiology, Nemours Children's Hospital, Delaware, Wilmington, DE 19803, USA.
Abdulhafeez KhairDepartment of Radiology, Nemours Children's Hospital, Delaware, Wilmington, DE 19803, USA.
Heidi H KecskemethyDepartment of Radiology, Nemours Children's Hospital, Delaware, Wilmington, DE 19803, USA.
Lauren W AverillDepartment of Radiology, Nemours Children's Hospital, Delaware, Wilmington, DE 19803, USA.
Sigrid A LanghansNemours Diagnostic & Research PET/MR Center, Nemours Children's Hospital, Delaware, Wilmington, DE 19803, USA.ORCID 0000-0003-4695-7468

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Anjana Narayan Bhat · 2012 to 2026
$67.2M
Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI Megan M Wenner · 2013 to 2026
$60.5M
Targeting mechanosignaling in pediatric brain cancerR01CA263216 · NCI · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · PI Sigrid A Langhans · 2022 to 2026
$1.6M
NCI NIH HHS R01 CA263216NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P20GM103446NIGMS NIH HHS U54 GM104941NIGMS NIH HHS U54-GM104941
6 · The paper itself

Abstract

Central nervous system tumors are the most common pediatric solid tumors; they are also the most lethal. Unlike adults, childhood brain tumors are mostly primary in origin and differ in type, location and molecular signature. Tumor characteristics (incidence, location, and type) vary with age. Children present with a variety of symptoms, making early accurate diagnosis challenging. Neuroimaging is key in the initial diagnosis and monitoring of pediatric brain tumors. Conventional anatomic imaging approaches (computed tomography (CT) and magnetic resonance imaging (MRI)) are useful for tumor detection but have limited utility differentiating tumor types and grades. Advanced MRI techniques (diffusion-weighed imaging, diffusion tensor imaging, functional MRI, arterial spin labeling perfusion imaging, MR spectroscopy, and MR elastography) provide additional and improved structural and functional information. Combined with positron emission tomography (PET) and single-photon emission CT (SPECT), advanced techniques provide functional information on tumor metabolism and physiology through the use of radiotracer probes. Radiomics and radiogenomics offer promising insight into the prediction of tumor subtype, post-treatment response to treatment, and prognostication. In this paper, a brief review of pediatric brain cancers, by type, is provided with a comprehensive description of advanced imaging techniques including clinical applications that are currently utilized for the assessment and evaluation of pediatric brain tumors.

Indexed as

brain tumorelastographypediatricspositron emission tomographyvolumetrics

Identifiers

PMID35884462
PMCPMC9318188

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.