ArticleCancers2022
Brain Functional Connectivity in Low- and High-Grade Gliomas: Differences in Network Dynamics Associated with Tumor Grade and Location.
Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gut-brain axis and neuroplasticity in health and disease: a systematic review.La Radiologia medica · 2025Pooled it
- Disrupted dynamics of transient brain states in patients with brain tumors: a co-activation pattern analysis of resting-state fMRI.La Radiologia medica · 2026Article
- Machine-Learning-Based Survival Prediction in Glioblastoma Using Graph-Theoretical Analysis of Structural Network Alterations.Cancers · 2026Article
- Anomaly Detection for Structural and Functional Connectivity in Glioma Patients.NMR in biomedicine · 2026Article
- Impact of meningioma and glioma on whole-brain dynamics.Scientific reports · 2026Article
- Daily locomotor activity declines with tumor growth and disease progression in glioblastoma.JCI insight · 2026Article
- Beyond synapses non-synaptic neural microenvironment interactions remodel circuits and drive glioma progression.Frontiers in oncology · 2026Review
- Resting-State Coactivation Patterns of Language Reorganization in Brain Tumors.Neural plasticity · 2026Article
- Relationship between functional network integrity, cognition and fatigue at long-term follow-up in patients with IDH-mutated gliomas.Frontiers in human neuroscience · 2026Article
- The impact of glioblastoma on the contralesional hemisphere: insights from structural connectivity and cortical surface analysis.Neuroradiology · 2025Article
- High peritumoral network connectedness in glioblastoma reveals a distinct epigenetic signature and is associated with decreased overall survival.Neuro-oncology · 2025Article
- Review
- Cognitive Control Network and Language Reorganization in Patients with Brain Tumors.AJNR. American journal of neuroradiology · 2025Article
- Changes on Cognition and Brain Network Temporal Variability After Pediatric Neurosurgery.Neurosurgery · 2025Article
- Radiosurgery for Hypothalamic Gliomas: A Case Report and Clinical Guidelines Form a Neurosurgical Center of Excellence.Journal of personalized medicine · 2024Article
- Combination of MRI-based prediction and CRISPR/Cas12a-based detection for IDH genotyping in glioma.NPJ precision oncology · 2024Article
- Association of Lack of Speech Arrest During Cortical Stimulation With Interhemispheric Reorganization of the Functional Language Network in Patients With Brain Tumors.AJR. American journal of roentgenology · 2023Article
- Review
- Article
- Controllability and Robustness of Functional and Structural Connectomic Networks in Glioma Patients.Cancers · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Brain tumors lead to modifications of brain networks. Graph theory plays an important role in clarifying the principles of brain connectivity. Our objective was to investigate network modifications related to tumor grade and location using resting-state functional magnetic resonance imaging (fMRI) and graph theory. We retrospectively studied 30 low-grade (LGG), 30 high-grade (HGG) left-hemispheric glioma patients and 20 healthy controls (HC) with rs-fMRI. Tumor location was labeled as: frontal, temporal, parietal, insular or occipital. We collected patients’ clinical data from records. We analyzed whole-brain and hemispheric networks in all patients and HC. Subsequently, we studied lobar networks in subgroups of patients divided by tumor location. Seven graph-theoretical metrics were calculated (FDR p < 0.05). Connectograms were computed for significant nodes. The two-tailed Student t-test or Mann−Whitney U-test (p < 0.05) were used to compare graph metrics and clinical data. The hemispheric network analysis showed increased ipsilateral connectivity for LGG (global efficiency p = 0.03) and decreased contralateral connectivity for HGG (degree/cost p = 0.028). Frontal and temporal tumors showed bilateral modifications; parietal and insular tumors showed only local effects. Temporal tumors led to a bilateral decrease in all graph metrics. Tumor grade and location influence the pattern of network reorganization. LGG may show more favorable network changes than HGG, reflecting fewer clinical deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.