Evidence map›Paper›PMID 35884329›Full record

ArticleBiosensors2022

Large Area Microfluidic Bioreactor for Production of Recombinant Protein.

Natalia Bourguignon, Paola Karp, Carolina Attallah, Daniel A Chamorro, Marcos Oggero, Ross Booth, Sol Ferrero, Shekhar Bhansali, Maximiliano S Pérez, Betiana Lerner and 1 more

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Microbioreactor design for eukaryotic cell-based biomedical applications.Frontiers in bioengineering and biotechnology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Natalia BourguignonCentro IREN, Universidad Tecnológica Nacional, Haedo B1706EAH, Provincia de Buenos Aires, Argentina.ORCID 0000-0001-6359-7340
Paola KarpLaboratorio de Biotecnología Farmacéutica, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Ciudad de Buenos Aires C1428ADN, Argentina.
Carolina AttallahCentro Biotecnológico del Litoral, Laboratorio de Cultivos Celulares, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral (UNL), CONICET, Santa Fe S3000ZAA, Provincia de Santa Fe, Argentina.
Daniel A ChamorroCentro IREN, Universidad Tecnológica Nacional, Haedo B1706EAH, Provincia de Buenos Aires, Argentina.
Marcos OggeroCentro Biotecnológico del Litoral, Laboratorio de Cultivos Celulares, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral (UNL), CONICET, Santa Fe S3000ZAA, Provincia de Santa Fe, Argentina.
Ross BoothRoche Sequencing Solutions, Inc., Pleasanton, CA 94588, USA.
Sol FerreroLaboratorio de Biotecnología Farmacéutica, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Ciudad de Buenos Aires C1428ADN, Argentina.
Shekhar BhansaliDepartment of Electrical and Computer Engineering, Florida International University, Miami, FL 33174, USA.ORCID 0000-0001-5871-9163
Maximiliano S PérezCentro IREN, Universidad Tecnológica Nacional, Haedo B1706EAH, Provincia de Buenos Aires, Argentina.
Betiana LernerCentro IREN, Universidad Tecnológica Nacional, Haedo B1706EAH, Provincia de Buenos Aires, Argentina.ORCID 0000-0003-3341-5686
Gustavo HelgueraLaboratorio de Biotecnología Farmacéutica, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Ciudad de Buenos Aires C1428ADN, Argentina.ORCID 0000-0003-1509-3564
Consejo Nacional de Investigaciones Científicas y Técnicas · ARNational Technological University · ARFlorida International University · USLa Roche College · US

Funding

Agencia Nacional de Promoción Científica y Tecnológica IP-COVID19 939Agencia Nacional de Promoción Científica y Tecnológica PICT 2018-1697Agencia Nacional de Promoción Científica y Tecnológica PICT 2018-3954Agencia Nacional de Promoción Científica y Tecnológica PID 2015-0034Instituto Nacional del Cáncer (Argentina) INC IV ISO02427 2018-2020National Scientific and Technical Research Council PIP 2021-2023 11220200101707CO
6 · The paper itself

Abstract

To produce innovative biopharmaceuticals, highly flexible, adaptable, robust, and affordable bioprocess platforms for bioreactors are essential. In this article, we describe the development of a large-area microfluidic bioreactor (LM bioreactor) for mammalian cell culture that works at laminar flow and perfusion conditions. The 184 cm

Indexed as

BioreactorsMicrofluidicsAnimalsAntibodies, MonoclonalCell Culture TechniquesCHO CellsCricetinaeCricetulusRecombinant ProteinsAntibodies, MonoclonalRecombinant Proteinsantibody activityanti-hIFN-α2bcell culturelarge-areamicrofluidic bioreactormonoclonal antibody

Identifiers

PMID35884329
PMCPMC9313365
OpenAlexW4285595594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.