Evidence map›Paper›PMID 35884318›Full record

ArticleBiosensors2022

Differential Refractometric Biosensor for Reliable Human IgG Detection: Proof of Concept.

João P Mendes, Luís C C Coelho, Pedro A S Jorge, Carlos M Pereira

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

João P MendesCentro de Investigação em Química UP (CIQUP)-Instituto de Ciências Moleculares (IMS), Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, 687, 4169-007 Porto, Portugal.ORCID 0000-0003-1031-9261
Luís C C CoelhoINESC TEC-Instituto de Engenharia de Sistemas e Computadores, Tecnologia e Ciência, Departamento de Física e Astronomia, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, 687, 4169-007 Porto, Portugal.ORCID 0000-0001-6205-9479
Pedro A S JorgeINESC TEC-Instituto de Engenharia de Sistemas e Computadores, Tecnologia e Ciência, Departamento de Física e Astronomia, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, 687, 4169-007 Porto, Portugal.ORCID 0000-0003-1484-2068
Carlos M PereiraCentro de Investigação em Química UP (CIQUP)-Instituto de Ciências Moleculares (IMS), Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, 687, 4169-007 Porto, Portugal.ORCID 0000-0002-8392-9581
Universidade do Porto · PT

Funding

Fundação para a Ciência e Tecnologia CEECIND/00471/2017Fundação para a Ciência e Tecnologia SFRH/BD/130674/2017Fundação para a Ciência e Tecnologia UIDB/00081/2020Fundação para a Ciência e Tecnologia UIDB/50014/2020
6 · The paper itself

Abstract

A new sensing platform based on long-period fiber gratings (LPFGs) for direct, fast, and selective detection of human immunoglobulin G (IgG; Mw = 150 KDa) was developed and characterized. The transducer's high selectivity is based on the specific interaction of a molecularly imprinted polymer (MIPs) design for IgG detection. The sensing scheme is based on differential refractometric measurements, including a correction system based on a non-imprinted polymer (NIP)-coated LPFG, allowing reliable and more sensitive measurements, improving the rejection of false positives in around 30%. The molecular imprinted binding sites were performed on the surface of a LPFG with a sensitivity of about 130 nm/RIU and a FOM of 16 RIU

Indexed as

Biosensing TechniquesMolecular ImprintingHumansImmunoglobulin GLimit of DetectionPolymersImmunoglobulin GPolymersIgG antibodieslong period fiber gratingsmolecular imprintingoptical sensingrefractometric platform

Identifiers

PMID35884318
PMCPMC9312733
OpenAlexW4285091874

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.