Evidence map›Paper›PMID 35884299›Full record

ArticleBiosensors2022

Microfluidic Sliding Paper-Based Device for Point-of-Care Determination of Albumin-to-Creatine Ratio in Human Urine.

Szu-Jui Chen, Chin-Chung Tseng, Kuan-Hsun Huang, Yu-Chi Chang, Lung-Ming Fu

Abstract read
In one paragraph

Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Szu-Jui ChenDepartment of Engineering Science, National Cheng Kung University, Tainan 701, Taiwan.ORCID 0000-0002-6406-9280
Chin-Chung TsengDivision of Nephrology, Department of Internal Medicine, National Cheng Kung University Hospital Dou-Liou Branch, College of Medicine, National Cheng Kung University, Yunlin 640, Taiwan.
Kuan-Hsun HuangDepartment of Engineering Science, National Cheng Kung University, Tainan 701, Taiwan.
Yu-Chi ChangDepartment of Engineering Science, National Cheng Kung University, Tainan 701, Taiwan.ORCID 0000-0003-2253-935X
Lung-Ming FuDepartment of Engineering Science, National Cheng Kung University, Tainan 701, Taiwan.ORCID 0000-0002-5422-3811

Funding

Ministry of Science and Technology of Taiwan MOST 106-2314-B-006-085-MY3, MOST 109-2221-E-006-043-MY3, MOST 109-2622-E-006-009-CC2, MOST 110-2622-E-006-003-CC2, MOST 110-2314-B-006-030
6 · The paper itself

Abstract

A novel assay platform consisting of a microfluidic sliding double-track paper-based chip and a hand-held Raspberry Pi detection system is proposed for determining the albumin-to-creatine ratio (ACR) in human urine. It is a clinically important parameter and can be used for the early detection of related diseases, such as renal insufficiency. In the proposed method, the sliding layer of the microchip is applied and the sample diffuses through two parallel filtration channels to the reaction/detection areas of the microchip to complete the detection reaction, which is a simple method well suited for self-diagnosis of ACR index in human urine. The RGB (red, green, and blue) value intensity signals of the reaction complexes in these two reaction zones are analyzed by a Raspberry Pi computer to derive the ACR value (ALB and CRE concentrations). It is shown that the G + B value intensity signal is linearly related to the ALB and CRE concentrations with the correlation coefficients of R

Indexed as

CreatineRenal Insufficiency, ChronicAlbuminsCreatinineHumansMicrofluidicsPoint-of-Care SystemsReproducibility of ResultsAlbuminsCreatineCreatininealbumincolorimetriccreatininepaper-based

Identifiers

PMID35884299
PMCPMC9313340

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.