A Fast-Response AIE-Active Ratiometric Fluorescent Probe for the Detection of Carboxylesterase.

Mengting Xia, Chunbin Li, Lingxiu Liu, Yumao He, Yongdong Li, Guoyu Jiang, Jianguo Wang

Abstract read

In one paragraph

Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Mengting XiaKey Laboratory of Organo-Pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, China.

Chunbin LiCollege of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China.

Lingxiu LiuCollege of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China.

Yumao HeCollege of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China.

Yongdong LiKey Laboratory of Organo-Pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, China.

Guoyu JiangCollege of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China.

Jianguo WangCollege of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China.

Funding

National Natural Science Foundation of China 22165020, 22161034 and 21871060Natural Science Foundation of Inner Mongolia Autonomous Region of China 2020JQ02 and 2020MS02004the Natural Science Foundation of Jiangxi Province 20192BCBL23013the Science and Technology Program of Inner Mongolia 2021GG0154Young science and technology talents cultivation project of Inner Mongolia University 21221505

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is associated with a high mortality rate worldwide. The therapeutic outcomes can be significantly improved if diagnosis and treatment are initiated earlier in the disease process. Recently, the carboxylesterase (CaE) activity/level in human plasma was reported to be a novel serological biomarker candidate for HCC. In this article, we fabricated a new fluorescent probe with AIE characteristics for the rapid detection of CaE with a more reliable ratiometric response mode. The TCFISE probe showed high sensitivity (LOD: 93.0 μU/mL) and selectivity toward CaE. Furthermore, the good pH stability, superior resistance against photobleaching, and low cytotoxicity highlight the high potential of the TCFISE probe for application in the monitoring of CaE activity in complex biological samples and in live cells, tissues, and animals.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAnimalsCarboxylesteraseFluorescent DyesHumansSpectrometry, FluorescenceCarboxylesteraseFluorescent Dyesaggregation-induced emissioncarboxylesterasefluorescent probehepatocellular carcinomaratiometric

Identifiers

PMID35884287

DOI10.3390/bios12070484

PMCPMC9313056

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.