ReviewAntibiotics (Basel, Switzerland)2022
Predictive Scores for Late-Onset Neonatal Sepsis as an Early Diagnostic and Antimicrobial Stewardship Tool: What Have We Done So Far?
Review in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Clinical prediction models to diagnose neonatal sepsis in low-income and middle-income countries: a scoping review.BMJ global health · 2025Article
- Neonatal Sepsis: A Comprehensive Review.Antibiotics (Basel, Switzerland) · 2024Review
- Differences in maternal-newborn ABO blood groups and risk of serious infant infection.QJM : monthly journal of the Association of Physicians · 2024Article
- Predictive Role of Maternal Laboratory Parameters and Inflammatory Scores in Determining Systemic Inflammatory Response Syndrome in Newborns at Birth.Journal of personalized medicine · 2024Article
- Insight Into Neonatal Sepsis: An Overview.Cureus · 2023Review
- The Role of Coagulase-Negative Staphylococci Biofilms on Late-Onset Sepsis: Current Challenges and Emerging Diagnostics and Therapies.Antibiotics (Basel, Switzerland) · 2023Review
- Antibiotic Resistance and Biofilm Infections in the NICUs and Methods to Combat It.Antibiotics (Basel, Switzerland) · 2023Review
- Early Diagnosis of Late-Onset Neonatal Sepsis Using a Sepsis Prediction Score.Microorganisms · 2023Article
- Development and validation of a sepsis diagnostic scoring model for neonates with suspected sepsis.Frontiers in pediatrics · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLate-onset neonatal sepsis (LOS) represents a significant cause of morbidity and mortality worldwide, and early diagnosis remains a challenge. Various 'sepsis scores' have been developed to improve early identification. The aim of the current review is to summarize the current knowledge on the utility of predictive scores in LOS as a tool for early sepsis recognition, as well as an antimicrobial stewardship tool.
methodsThe following research question was developed: Can we diagnose LOS with accuracy in neonates using a predictive score? A systematic search was performed in the PubMed database from 1982 (first predictive score published) to December 2021.
resultsSome (1352) articles were identified-out of which, 16 were included in the review. Eight were original scores, five were validations of already existing scores and two were mixed. Predictive models were developed by combining a variety of clinical, laboratory and other variables. The majority were found to assist in early diagnosis, but almost all had a limited diagnostic accuracy.
conclusionsThere is an increasing need worldwide for a simple and accurate score to promptly predict LOS. Combinations of the selected parameters may be helpful, but until now, a single score has not been proven to be comprehensive.
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