Evidence map›Paper›PMID 35883974›Full record

ArticleChildren (Basel, Switzerland)2022

Predictors of Early Language Outcomes in Children with Connexin 26 Hearing Loss across Three Countries.

Daniel Holzinger, Magdalena Dall, Sandra Kiblböck, Evelien Dirks, Peter Carew, Libby Smith, Lilian Downie, Daisy A Shepherd, Valerie Sung

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Children (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Daniel HolzingerInstitute of Neurology of Senses and Language, Hospital of St. John of God, 4020 Linz, Austria.ORCID 0000-0001-6634-6117
Magdalena DallResearch Institute for Developmental Medicine, Johannes Kepler University, 4020 Linz, Austria.
Sandra KiblböckInstitute of Neurology of Senses and Language, Hospital of St. John of God, 4020 Linz, Austria.
Evelien DirksDutch Foundation for the Deaf and Hard of Hearing Child, 1073 GX Amsterdam, The Netherlands.ORCID 0000-0003-4391-4462
Peter CarewMurdoch Children's Research Institute, Parkville, Melbourne, VIC 3052, Australia.ORCID 0000-0003-4133-5723
Libby SmithMurdoch Children's Research Institute, Parkville, Melbourne, VIC 3052, Australia.
Lilian DownieMurdoch Children's Research Institute, Parkville, Melbourne, VIC 3052, Australia.
Daisy A ShepherdMurdoch Children's Research Institute, Parkville, Melbourne, VIC 3052, Australia.
Valerie SungMurdoch Children's Research Institute, Parkville, Melbourne, VIC 3052, Australia.
Johannes Kepler University of Linz · ATThe University of Melbourne · AUMurdoch Children's Research Institute · AURoyal Children's Hospital · AUUtrecht University · NL

Funding

Kyle Patrick Lamsam Convery Foundation n/aL'Oreal-UNESCO Australian & New Zealand For Women in Science Fellowship 2019 n/aMED-EL (Austria) n/aMelbourne Children's Clinician Scientist Fellowship 2021 n/aMurdoch Children's Research Institute, the Centre for Research Excellence-Child Language CRE-CL1023493National Health and Medical Research Council (NHMRC) Early Career Fellowship 1125687Nelson Alexander Charitable Foundation n/aPhyllis Connor Memorial Trust n/aRoyal Australasian College of Physicians Cottrell Research Establishment Fellowship n/aThe Royal Children's Hospital Foundation Grants 2014-430The Royal Children's Hospital Foundation Grants 2018-999Victorian Government's Operational Infrastructure Support Program n/a
6 · The paper itself

Abstract

GJB2-associated hearing loss (GJB2-HL) is the most common genetic cause of hearing loss in children. However, little is known about the clinical characteristics and early language outcomes in population-oriented samples including children with different degrees of hearing loss. Insight into these characteristics are relevant for the counselling of parents. Our sample consisted of 66 children at approximately 2 years of age (17-32 months) with bilateral hearing loss due to GJB2 from three population-based cohorts in Austria, Australia and the Netherlands. Predictors of early vocabulary, including demographic, audiological, genetic and intervention variables and the role of medical comorbidities and nonverbal cognition were examined. The vocabulary scores of children with GJB2-HL were approximately 0.7 standard deviations (SDs) below the norms of children with typical hearing. Age at access to family-centered early intervention and first-born position among siblings predicted language outcomes, whereas the degree of hearing loss and genetic subtype were not significantly correlated with expressive vocabulary. In children with GJB2-HL, early access to family-centered early intervention significantly affected language outcomes at the age of two.

Indexed as

clinical characteristicsconnexin 26expressive vocabularyGJB2hearing lossphenotype

Identifiers

PMID35883974
PMCPMC9324687
OpenAlexW4283769280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.