Evidence map›Paper›PMID 35883970›Full record

ArticleChildren (Basel, Switzerland)2022

Impact of Time Point of Extracorporeal Membrane Oxygenation on Mortality and Morbidity in Congenital Diaphragmatic Hernia: A Single-Center Case Series.

Christian Wegele, Yannick Schreiner, Alba Perez Ortiz, Svetlana Hetjens, Christiane Otto, Michael Boettcher, Thomas Schaible, Neysan Rafat

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Children (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christian WegeleDepartment of Neonatology, University Children's Hospital Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Yannick SchreinerDepartment of Neonatology, University Children's Hospital Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Alba Perez OrtizDepartment of Neonatology, University Children's Hospital Mannheim, University of Heidelberg, 68167 Mannheim, Germany.ORCID 0000-0003-2246-7982
Svetlana HetjensDepartment of Biomathematics and Medical Statistics, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Christiane OttoDepartment of Obstetrics and Gynecology, University Medical Center Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Michael BoettcherDepartment of Pediatric Surgery, University Children's Hospital Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Thomas SchaibleDepartment of Neonatology, University Children's Hospital Mannheim, University of Heidelberg, 68167 Mannheim, Germany.
Neysan RafatDepartment of Neonatology, University Children's Hospital Mannheim, University of Heidelberg, 68167 Mannheim, Germany.ORCID 0000-0003-2035-8598

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since there are no data available on the influence of the time point of ECMO initiation on morbidity and mortality in patients with congenital diaphragmatic hernia (CDH), we investigated whether early initiation of ECMO after birth is associated with a beneficial outcome in severe forms of CDH. All neonates with CDH admitted to our institution between 2010 until 2020 and undergoing ECMO treatment were included in this study and divided into four different groups: (1) ECMO initiation < 12 h after birth (n = 143), (2) ECMO initiation between 12−24 h after birth (n = 31), (3) ECMO initiation between 24−120 h after birth (n = 48) and (4) ECMO initiation > 120 h after birth (n = 14). The mortality rate in the first (34%) and fourth group (43%) was high and in the second group (23%) and third group (12%) rather low. The morbidity, characterized by chronic lung disease (CLD), did not differ significantly in the three groups; only patients in which ECMO was initiated >120 h after birth had an increased rate of severe CLD. Our data, although not randomized and limited due to small study groups, suggest that very early need for ECMO and ECMO initiation > 120 h after birth is associated with increased mortality.

Indexed as

chronic lung diseasecongenital diaphragmatic herniaextracorporeal membrane oxygenation

Identifiers

PMID35883970
PMCPMC9315500

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.