Evidence map›Paper›PMID 35883889›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Computation-Assisted Identification of Bioactive Compounds in Botanical Extracts: A Case Study of Anti-Inflammatory Natural Products from Hops.

Kevin S Brown, Paige Jamieson, Wenbin Wu, Ashish Vaswani, Armando Alcazar Magana, Jaewoo Choi, Luce M Mattio, Paul Ha-Yeon Cheong, Dylan Nelson, Patrick N Reardon and 3 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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  8. Role ofAntioxidants (Basel, Switzerland) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Kevin S BrownDepartment of Pharmaceutical Sciences, Oregon State University, 1601 SW Jefferson Way, Corvallis, OR 97331, USA.ORCID 0000-0003-2959-2401
Paige JamiesonLinus Pauling Institute, Oregon State University, 2900 SW Campus Way, Corvallis, OR 97331, USA.
Wenbin WuDepartment of Pharmaceutical Sciences, Oregon State University, 1601 SW Jefferson Way, Corvallis, OR 97331, USA.
Ashish VaswaniDepartment of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, OR 97331, USA.
Armando Alcazar MaganaDepartment of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, OR 97331, USA.ORCID 0000-0002-4731-0247
Jaewoo ChoiLinus Pauling Institute, Oregon State University, 2900 SW Campus Way, Corvallis, OR 97331, USA.
Luce M MattioDepartment of Pharmaceutical Sciences, Oregon State University, 1601 SW Jefferson Way, Corvallis, OR 97331, USA.ORCID 0000-0003-0955-3982
Paul Ha-Yeon CheongDepartment of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, OR 97331, USA.
Dylan NelsonDepartment of Pharmaceutical Sciences, Oregon State University, 1601 SW Jefferson Way, Corvallis, OR 97331, USA.
Patrick N ReardonDepartment of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, OR 97331, USA.
Cristobal L MirandaLinus Pauling Institute, Oregon State University, 2900 SW Campus Way, Corvallis, OR 97331, USA.
Claudia S MaierDepartment of Chemistry, Oregon State University, 153 Gilbert Hall, Corvallis, OR 97331, USA.
Jan F StevensDepartment of Pharmaceutical Sciences, Oregon State University, 1601 SW Jefferson Way, Corvallis, OR 97331, USA.ORCID 0000-0002-6348-9347
Oregon State University · US

Funding

Triple Quadrupole/Linear Ion Trap LC-MS/MS for LPIS10RR027878 · NCRR · OREGON STATE UNIVERSITY · PI STEVENS, JAN FREDERIK · 2010 to 2010
$484k
HYBRID TRIPLE QUADRUPOLE LINEAR ION TRAP MASS SPECTROMETER: PROSTATE CANCERS10RR022589 · NCRR · OREGON STATE UNIVERSITY · PI STEVENS, JAN FREDERIK · 2006 to 2006
$343k
NIH HHS S10RR022589NIH HHS S10RR027878OSU Foundation Buhler-Wang Research Fund
6 · The paper itself

Abstract

The slow pace of discovery of bioactive natural products can be attributed to the difficulty in rapidly identifying them in complex mixtures such as plant extracts. To overcome these hurdles, we explored the utility of two machine learning techniques, i.e., Elastic Net and Random Forests, for identifying the individual anti-inflammatory principle(s) of an extract of the inflorescences of the hops (

Indexed as

bioassayElastic NetHumulus lupulusinflammationmachine learningmass spectrometryprenylated flavonoidsRandom Forestsspectral networkxanthohumol

Identifiers

PMID35883889
PMCPMC9312012
OpenAlexW4285799360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.