Evidence map›Paper›PMID 35883834›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Influence of Plasma-Isolated Anthocyanins and Their Metabolites on Cancer Cell Migration (HT-29 and Caco-2) In Vitro: Results of the ATTACH Study.

Inken Behrendt, Isabella Röder, Frank Will, Hamza Mostafa, Raúl Gonzalez-Dominguez, Tomás Meroño, Cristina Andres-Lacueva, Mathias Fasshauer, Silvia Rudloff, Sabine Kuntz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Biomarkers of Berry Intake: Systematic Review Update.Journal of agricultural and food chemistry · 2023
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Inken BehrendtDepartment of Nutritional Science, Human Nutrition, Justus-Liebig-University, 35390 Giessen, Germany.
Isabella RöderDepartment of Beverage Research, Hochschule Geisenheim University, 65366 Geisenheim, Germany.
Frank WillDepartment of Beverage Research, Hochschule Geisenheim University, 65366 Geisenheim, Germany.ORCID 0000-0003-0369-3087
Hamza MostafaBiomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Food Innovation Network (XIA), Nutrition and Food Safety Research Institute (INSA), Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona (UB), 08028 Barcelona, Spain.ORCID 0000-0003-4319-9542
Raúl Gonzalez-DominguezBiomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Food Innovation Network (XIA), Nutrition and Food Safety Research Institute (INSA), Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona (UB), 08028 Barcelona, Spain.ORCID 0000-0002-7640-8833
Tomás MeroñoBiomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Food Innovation Network (XIA), Nutrition and Food Safety Research Institute (INSA), Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona (UB), 08028 Barcelona, Spain.ORCID 0000-0002-2673-3494
Cristina Andres-LacuevaBiomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Food Innovation Network (XIA), Nutrition and Food Safety Research Institute (INSA), Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona (UB), 08028 Barcelona, Spain.ORCID 0000-0002-8494-4978
Mathias FasshauerDepartment of Nutritional Science, Human Nutrition, Justus-Liebig-University, 35390 Giessen, Germany.
Silvia RudloffDepartment of Nutritional Science and Department of Pediatrics, Justus-Liebig-University, 35392 Giessen, Germany.
Sabine KuntzDepartment of Nutritional Science, Human Nutrition, Justus-Liebig-University, 35390 Giessen, Germany.
Instituto de Salud Carlos III · ESJustus-Liebig-Universität Gießen · DEHochschule Geisenheim University · DE

Funding

Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable AC19/00096Deutsche Forschungsgemeinschaft 1925/5-1Instituto de Salud Carlos III AGAUR [2017SGR1546]
6 · The paper itself

Abstract

Cancer mortality is mainly due to metastasis. Therefore, searching for new therapeutic agents suppressing cancer cell migration is crucial. Data from human studies regarding effects of anthocyanins on cancer progression, however, are scarce and it is unclear whether physiological concentrations of anthocyanins and their metabolites reduce cancer cell migration in vivo. In addition, interactions with chemotherapeutics like 5-fluorouracil (5-FU) are largely unknown. Thus, we combined a placebo-controlled, double-blinded, cross-over study with in vitro migration studies of colon cancer cell lines to examine the anti-migratory effects of plasma-isolated anthocyanins and their metabolites (PAM). Healthy volunteers (

Indexed as

5-fluorouracilanthocyaninsantioxidant capacitybilberrycolon cancergrapesintervention studyjuicemigration

Identifiers

PMID35883834
PMCPMC9311669
OpenAlexW4284971952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.