Evidence map›Paper›PMID 35883821›Full record

ArticleAntioxidants (Basel, Switzerland)2022

HBOC-301 in Porcine Kidney Normothermic Machine Perfusion and the Effect of Vitamin C on Methemoglobin Formation.

Eileen Edgworth, Lisa Ernst, Zoltan Czigany, Turgay Saritas, Laura Sophie Zarnitz, Marc Wiartalla, Peter Boor, Eva Miriam Buhl, Rolf Rossaint, René H Tolba and 3 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Eileen EdgworthDepartment of Anesthesiology, Medical Faculty, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Lisa ErnstInstitute for Laboratory Animal Science and Experimental Surgery, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Zoltan CziganyDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0003-0373-3210
Turgay SaritasDivision of Nephrology and Immunology, University Hospital RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0002-6691-9218
Laura Sophie ZarnitzDepartment of Anesthesiology, Medical Faculty, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Marc WiartallaInstitute of Computer Sciences 11, RWTH Aachen University, 52074 Aachen, Germany.
Peter BoorInstitute of Pathology, Division of Nephrology, Medical Faculty, RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0001-9921-4284
Eva Miriam BuhlInstitute of Pathology, Division of Nephrology, Medical Faculty, RWTH Aachen, 52074 Aachen, Germany.ORCID 0000-0003-0627-9228
Rolf RossaintDepartment of Anesthesiology, Medical Faculty, University Hospital RWTH Aachen, 52074 Aachen, Germany.
René H TolbaInstitute for Laboratory Animal Science and Experimental Surgery, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Benedict DoorschodtInstitute for Laboratory Animal Science and Experimental Surgery, Faculty of Medicine, RWTH Aachen University, 52074 Aachen, Germany.
Gregor FabryDepartment of Anesthesiology, Medical Faculty, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Christian BleilevensDepartment of Anesthesiology, Medical Faculty, University Hospital RWTH Aachen, 52074 Aachen, Germany.
RWTH Aachen University · DE

Funding

Federal Ministry of Education and Research 161L0253A and B
6 · The paper itself

Abstract

Normothermic machine perfusion (NMP) of kidneys in combination with an optimized perfusate composition may increase donor organ preservation quality, especially in the case of marginal donor grafts. Optimization of currently employed perfusates is still a subject of present research. Due to the advantages of being cell-free, easy to store, and having minimal antigenicity, hemoglobin-based oxygen carriers, such as HBOC-301 (Oxyglobin

Indexed as

hemoglobin-based oxygen carrierischemia reperfusion injurykidney preservationkidney transplantationnormothermic machine perfusion

Identifiers

PMID35883821
PMCPMC9311674
OpenAlexW4283826197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.