Evidence map›Paper›PMID 35883495›Full record

ReviewBiomolecules2022

Research Progress of DNA Methylation in Endometrial Cancer.

Ting Xu, Hongmei Ding, Jie Chen, Jiahui Lei, Meng Zhao, Bingyu Ji, Youguo Chen, Songbing Qin, Qinqin Gao

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 30 citations in OpenAlex.

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  14. E2F1-induced upregulation ofHistology and histopathology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ting XuInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Hongmei DingDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Jie ChenDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Jiahui LeiInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Meng ZhaoInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Bingyu JiInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Youguo ChenDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Songbing QinDepartment of Radiation Oncology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Qinqin GaoInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Soochow University · CNFirst Affiliated Hospital of Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometrial cancer (EC)) is one of the most common malignant tumors of the female genital system, with an increasing incidence and mortality, worldwide. Although the therapeutic strategy of EC is still complicated and challenging, further understanding of carcinogenesis from a gene perspective would allow an effort to improve therapeutic precision in this complex malignancy. DNA methylation is the most widely studied epigenetic alteration in human tumors. Aberrant DNA methylation events, resulting in altered gene expression, are features of many tumor types. In this review, we provide an update on evidence about the roles of aberrant DNA methylation within some classical tumor suppressor genes and oncogenes in endometrial carcinogenesis, and report on recent advances in the understanding of the contribution of aberrant DNA methylation to EC, as well as opportunities and challenges of DNA methylation in EC management and prevention.

Indexed as

DNA MethylationEndometrial NeoplasmsCarcinogenesisEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticHumansDNA methylationendometrial canceroncogenestumor suppressor genes

Identifiers

PMID35883495
PMCPMC9312849
OpenAlexW4283802217

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.