Evidence map›Paper›PMID 35883346›Full record

ArticleAnimals : an open access journal from MDPI2022

Stimbiotic Supplementation Alleviates Poor Performance and Gut Integrity in Weaned Piglets Induced by Challenge with

DongCheol Song, JiHwan Lee, WooGi Kwak, MinHo Song, HanJin Oh, YongJu Kim, JaeWoo An, SeYeon Chang, YoungBin Go, HyunAh Cho and 2 more

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Effects of dietary supplementation ofJournal of animal science and technology · 2023
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

DongCheol SongDepartment of Animal Sciences, Chungbuk National University, Cheongju 286-44, Korea.ORCID 0000-0002-5704-603X
JiHwan LeeDepartment of Animal Sciences, Chungbuk National University, Cheongju 286-44, Korea.
WooGi KwakDepartment of Animal Sciences, Chungbuk National University, Cheongju 286-44, Korea.
MinHo SongDivision of Animal and Dairy Science, Chungnam National University, Daejeon 341-34, Korea.ORCID 0000-0002-4515-5212
HanJin OhDepartment of Animal Sciences, Chungbuk National University, Cheongju 286-44, Korea.ORCID 0000-0002-3396-483X
YongJu KimDepartment of Animal Sciences, Chungbuk National University, Cheongju 286-44, Korea.ORCID 0000-0002-0960-0884
JaeWoo AnDepartment of Animal Sciences, Chungbuk National University, Cheongju 286-44, Korea.
SeYeon ChangDepartment of Animal Sciences, Chungbuk National University, Cheongju 286-44, Korea.
YoungBin GoDepartment of Animal Sciences, Chungbuk National University, Cheongju 286-44, Korea.
HyunAh ChoDepartment of Animal Sciences, Chungbuk National University, Cheongju 286-44, Korea.
HyeunBum KimDepartment of Animal Resource and Science, Dankook University, Cheonan 311-16, Korea.
JinHo ChoDepartment of Animal Sciences, Chungbuk National University, Cheongju 286-44, Korea.

Funding

National Research Foundation of Korea NRF-2021R1I1A3051928
6 · The paper itself

Abstract

The aim of this study was to investigate the effects of stimbiotic (STB), a xylanase and xylo-oligosaccharide complex. A total of 36 male weaned pigs with initial body weights of 8.49 ± 0.10 kg were used in a 3-week experiment. The experiment was conducted in a 2 × 3 factorial arrangement (six replicates/treatment) of treatments consisting of two levels of challenge (challenge and non-challenge) and three levels of STB (0, 0.5, and 1 g/kg diet). Supplementations STB 0.5 g/kg (STB5) and STB 1 g/kg (STB10) improved the G:F (p = 0.04) in piglets challenged with STEC. STB supplementation, which also decreased (p < 0.05) the white blood cells, neutrophils, lymphocytes, and expression levels of tumor necrosis factor-alpha and interleukin-6. Supplementations STB5 and STB10 improved (p < 0.01) the lymphocytes and neutrophils in piglets challenged with STEC on 14 dpi. Additionally, supplementations STB5 and STB10 improved (p < 0.01) the tumor necrosis factor-alpha in piglets challenged with STEC on 3 dpi. Supplementations STB5 and STB10 also improved the villus height-to-crypt depth ratio (p < 0.01) in piglets challenged with STEC. Supplementation with STB reduced (p < 0.05) the expression levels of calprotectin. In conclusion, STB could alleviate a decrease of the performance, immune response, and inflammatory response induced by the STEC challenge.

Indexed as

E. coligut healthimmune responsestimbiotic

Identifiers

PMID35883346
PMCPMC9312148

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.