Evidence map›Paper›PMID 35883145›Full record

ArticleMolecular brain2022

Copper ions, prion protein and Aβ modulate Ca levels in central nervous system myelin in an NMDA receptor-dependent manner.

Shigeki Tsutsui, Megan Morgan, Hugo Tedford, Haitao You, Gerald W Zamponi, Peter K Stys

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shigeki TsutsuiDepartment of Clinical Neurosciences, University of Calgary, Calgary, AB, T2N 4N1, Canada.
Megan MorganDepartment of Clinical Neurosciences, University of Calgary, Calgary, AB, T2N 4N1, Canada.
Hugo TedfordDepartment of Clinical Neurosciences, University of Calgary, Calgary, AB, T2N 4N1, Canada.
Haitao YouDepartment of Physiology and Pharmacology, University of Calgary, Calgary, AB, T2N 4N1, Canada.
Gerald W Zamponi *Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, T2N 4N1, Canada.
Peter K Stys *Department of Clinical Neurosciences, University of Calgary, Calgary, AB, T2N 4N1, Canada. pstys@ucalgary.ca.ORCID 0000-0003-0326-4194
University of Calgary · CA

Funding

CIHR
6 · The paper itself

Abstract

As in neurons, CNS myelin expresses N-Methyl-D-Aspartate Receptors (NMDARs) that subserve physiological roles, but have the potential to induce injury to this vital element. Using 2-photon imaging of myelinic Ca in live ex vivo mouse optic nerves, we show that Cu ions potently modulate Ca levels in an NMDAR-dependent manner. Chelating Cu in the perfusate induced a substantial increase in Ca levels, and also caused significant axo-myelinic injury. Myelinic NMDARs are shown to be regulated by cellular prion protein; only in prion protein KO optic nerves does application of NMDA + D-serine induce a large Ca increase, consistent with strong desensitization of these receptors in the presence of prion protein limiting Ca overload. Aβ

Indexed as

Myelin SheathReceptors, N-Methyl-D-AspartateAmyloid beta-PeptidesAnimalsCentral Nervous SystemCopperIonsMicePeptide FragmentsPrion ProteinsAmyloid beta-Peptidesamyloid beta-protein (1-42)CopperIonsPeptide FragmentsPrion ProteinsReceptors, N-Methyl-D-AspartateAlzheimer's diseaseBathocuproineGlutamate receptorProteolipid protein

Identifiers

PMID35883145
PMCPMC9327403
OpenAlexW4288068795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.