Evidence map›Paper›PMID 35883115›Full record

ArticleTrials2022

The e-mental health treatment in Stockholm myocardial infarction with non-obstructive coronaries or Takotsubo syndrome study (E-SMINC): a study protocol for a randomised controlled trial.

Erik M G Olsson, Fredrika Norlund, Elisabet Rondung, Sophia M Humphries, Claes Held, Patrik Lyngå, Jonas Spaak, Örjan Sundin, Runa Sundelin, Philip Leissner and 2 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04178434 (E-health Treatment of Stress and Anxiety in Stockholm Myocardial Infarction With Non-obstructive Coronaries Study), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04178434 narecruitingnot on this map

E-health Treatment of Stress and Anxiety in Stockholm Myocardial Infarction With Non-obstructive Coronaries Study

TypeinterventionalSponsorPer TornvallRan2021 to 2025Enrolled64ConditionsMyocardial InfarctionArmsInternet-based CBT intervention
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Erik M G OlssonDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden. erik.olsson@kbh.uu.se.ORCID http://orcid.org/0000-0002-1591-7407
Fredrika NorlundDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Elisabet RondungDepartment of Psychology and Social Work, Mid Sweden University, Östersund, Sweden.
Sophia M HumphriesDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Claes HeldDepartment of Medical Sciences, Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Patrik LyngåDepartment of Clinical Science and Education, Karolinska Institutet and Department of Cardiology, Södersjukhuset, Stockholm, Sweden.
Jonas SpaakDepartment of Clinical Sciences, Danderyd University Hospital, Karolinska Institutet, Stockholm, Sweden.
Örjan SundinDepartment of Psychology and Social Work, Mid Sweden University, Östersund, Sweden.
Runa SundelinDepartment of Clinical Science and Education, Karolinska Institutet and Department of Cardiology, Södersjukhuset, Stockholm, Sweden.
Philip LeissnerDepartment of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Lena KövameesSwedish Heart and Lung Association, Stockholm, Sweden.
Per TornvallDepartment of Clinical Science and Education, Karolinska Institutet and Department of Cardiology, Södersjukhuset, Stockholm, Sweden.
Uppsala University · SEKarolinska Institutet · SEMid Sweden University · SEKarolinska University Hospital · SESwedish Medical Association · SE

Funding

Hjärt-Lungfonden 20200221Riksförbundet HjärtLung 2019:41Riksförbundet HjärtLung 2020:21Vetenskapsrådet 2018-02655
6 · The paper itself

Abstract

backgroundIn the aftermath of a myocardial infarction with non-obstructive coronary arteries (MINOCA) or Takotsubo syndrome (TS), patients commonly express high levels of stress and anxiety. Current treatment alternatives rarely address these issues.

methodsThe study is a randomised controlled trial, where 90 patients with a discharge diagnosis of MINOCA or TS who also report symptoms of stress or anxiety will be randomised 2-6 weeks after their cardiac event. The treatment consists of 10 weeks of Internet-based cognitive behaviour therapy (CBT) and starts immediately after randomisation for the treatment group. The control group receives usual care. Main outcomes are symptoms of anxiety measured with the Hospital Anxiety and Depression scale, anxiety subscale, and perceived stress measured with the Perceived Stress Scale, 14-item version, 10 weeks after randomisation. Secondary measures include cardiac specific anxiety, symptoms of post-traumatic stress, quality of life, cortisol measured in hair and physiological stress responses (heart rate variability, blood pressure and saliva cortisol) during a stress procedure. Ten weeks after randomisation, the control group will also receive treatment. Long-term follow-up in the self-report measures mentioned above will be conducted 20 and 50 weeks after randomisation where the total group's development over time is followed, and the groups receiving intervention early versus late compared. DISCUSSION: At present, there are no randomised studies evaluating psychological treatment for patients with MINOCA or TS. There is an urgent need for treatment alternatives aiming at relieving stress and anxiety considering the high mental stress and anxiety levels observed in MINOCA and TS, leading to decreased quality of life. CBT aiming at reducing mental stress has been shown to be effective regarding prognosis in patients with coronary artery disease. The current protocol describes a randomised open-label controlled trial evaluating an Internet-based CBT program for reduction of stress and anxiety in patients with increased mental stress and/or anxiety with a discharge diagnosis of either MINOCA or TS.

trial registrationClinicalTrials.gov NCT04178434 . Registered on 26 November 2019.

Indexed as

Myocardial InfarctionTakotsubo CardiomyopathyHumansHydrocortisoneMental HealthQuality of LifeRandomized Controlled Trials as TopicTreatment OutcomeHydrocortisoneAnxietyCognitive behavioural therapyInternet-based interventionMINOCARandomised controlled trialStressTakotsubo syndrome

Identifiers

PMID35883115
PMCPMC9315084
OpenAlexW4288038146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.