ArticleBMC cardiovascular disorders2022
Early and midterm results of frozen elephant trunk operation with Evita open stent-graft in patients with Marfan syndrome: results of a multicentre study.
Article in BMC cardiovascular disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Frozen elephant trunk technique in redo aortic arch surgery: a step-by-step approach.Annals of cardiothoracic surgery · 2026Article
- Design, benefits, and use of a hybrid aortic arch stent graft.JTCVS open · 2025Article
- Hybrid prosthesis in frozen elephant trunk procedures for hereditary thoracic aortic diseases: a 14-year single-aortic center experience.Journal of cardiothoracic surgery · 2025Article
- Challenges in prompt identification and surgical correction of Marfan Syndrome aortic disease in a middle-income country: a case series study.Journal of cardiothoracic surgery · 2024Article
- E-vita OPEN NEO in the treatment of acute or chronic aortic pathologies: first interim results of the NEOS study.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2024Observational
- Genetic Basis, New Diagnostic Approaches, and Updated Therapeutic Strategies of the Syndromic Aortic Diseases: Marfan, Loeys-Dietz, and Vascular Ehlers-Danlos Syndrome.International journal of environmental research and public health · 2023Review
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9 authors at 7 institutions in 5 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundEndovascular treatment of patients with Marfan syndrome (MFS) is not recommended. Hybrid procedures such as frozen elephant trunk (FET), which combines stent-graft deployment with an integrated non-stented fabric graft for proximal grafting and suturing, have not been previously evaluated. The aim of this study was to assess the safety and feasibility of FET operation in patients with MFS.
methodsPatients enrolled in the International E-vita Open Registry (IEOR) who underwent FET procedure between January 2001 and February 2020 meeting Ghent criteria for MFS were included in the study. Early and midterm results were retrospectively analyzed. Preoperative, postoperative and follow-up computed tomography angiography scans were analysed.
resultsWe analyzed 37 patients [mean age 38 ± 11 years, 65% men]. Acute or chronic aortic dissection was present in 35 (95%) patients (14 and 21 patients respectively). Two (5%) patients had an aneurysm without dissection. Malperfusion syndrome was present in 4 patients. Twenty-nine (78%) patients had history of aortic surgical interventions. The 30-day and in-hospital mortality amounted to 8 and 14% respectively. False lumen exclusion was present in 73% in stented segment in last postoperative CT. The overall 5-year survival was 71% and freedom from reintervention downstream was 58% at 5 years. Of the nine patients who required reintervention for distal aortic disease, one patient died.
conclusionsFET operation for patients with MFS can be performed with acceptable mortality and morbidity. In long-term follow-up no reinterventions on the aortic arch were required. FET allows for easier second stage operations providing platform for surgical and endovascular reinterventions.
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