Evidence map›Paper›PMID 35882936›Full record

ArticleNature immunology2022

Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8

Qiang Shan, Shaoqi Zhu, Xia Chen, Jia Liu, Shuang Yuan, Xiang Li, Weiqun Peng, Hai-Hui Xue

Open access · greenAbstract read
In one paragraph

Article in Nature immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Exhausted CD8Nature immunology · 2026
    Article
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  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Pre-division TCF1 drop determines long-term CD8 T cell fates.bioRxiv : the preprint server for biology · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Qiang Shan *Center for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA.
Shaoqi Zhu *Department of Physics, The George Washington University, Washington, DC, USA.
Xia ChenCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA.
Jia LiuCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA.
Shuang YuanDepartment of Physics, The George Washington University, Washington, DC, USA.
Xiang LiDepartment of Physics, The George Washington University, Washington, DC, USA.ORCID 0000-0002-8931-3681
Weiqun PengDepartment of Physics, The George Washington University, Washington, DC, USA. wpeng@gwu.edu.ORCID 0000-0001-5521-9091
Hai-Hui XueCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA. haihui.xue@hmh-cdi.org.ORCID 0000-0002-9163-7669
George Washington University · USHackensack University Medical Center · USVA New Jersey Health Care System · US

Funding

Tcf/Lef-b-catenin in T cell identity and cancerR01AI112579 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2015 to 2026
$5.4M
Tcf/Lef and B-catenin pathway in follicular helper T cellsR01AI121080 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2016 to 2026
$4.6M
Ezh2 regulates follicular helper T cell differentiationR01AI139874 · NIAID · UNIVERSITY OF IOWA · PI PENG, WEIQUN, XUE, HAI-HUI · 2018 to 2022
$2.4M
Modulating costimulation pathways to improve follicular helper T cell and antibody responsesI01BX005771 · VA · VA NEW JERSEY HEALTH CARE SYSTEM · PI XUE, HAI-HUI · 2022 to 2025
–
BLRD VA I01 BX005771NIAID NIH HHS R01 AI112579NIAID NIH HHS R01 AI121080NIAID NIH HHS R01 AI139874
6 · The paper itself

Abstract

CD8

Indexed as

CD8-Positive T-LymphocytesSignal TransductionCytokinesGenomicsHomeostasisCytokines

Identifiers

PMID35882936
PMCPMC9579964
OpenAlexW4288069125

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.