ArticleTranslational psychiatry2022
Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis.
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Article in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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22citing papers in PubMed, 2 pooled it
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Estimating Multimodal Structural Brain Variability in Schizophrenia Spectrum Disorders: A Worldwide ENIGMA Study.The American journal of psychiatry · 2025Pooled it
- Normative Modeling of Brain Morphometry in Clinical High Risk for Psychosis.JAMA psychiatry · 2024Pooled it
- Hippocampal volume and persistent distressing psychotic-like experiences across early adolescence: the moderating role of physical activity.Schizophrenia research · 2026Article
- Decomposing neuroanatomical heterogeneity in depression: insights from an ENIGMA major depressive disorder working group study in 5146 individuals.Translational psychiatry · 2026Article
- Personalized Estimates of Brain Cortical Structural Similarity in Major Depressive Disorder: Evidence from a Multi-Site Neuroimaging Dataset.Diagnostics (Basel, Switzerland) · 2026Article
- Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study.Molecular psychiatry · 2026Article
- Clinical correlates and cognitive associations of the neutrophil-to-lymphocyte ratio in first-episode psychosis and at-risk mental states.Frontiers in psychiatry · 2026Article
- Neuroanatomical normative modelling in frontotemporal lobar degeneration: higher heterogeneity in the behavioural variant.Journal of neurology · 2025Article
- Multimodal evidence of mediodorsal thalamus-prefrontal circuit dysfunctions in clinical high-risk for psychosis: findings from a combined 7T fMRI, MRSI and sleep Hd-EEG study.Molecular psychiatry · 2025Article
- Timeframe for Conversion to Psychosis From Individuals at Clinical High-Risk: A Quantile Regression.Schizophrenia bulletin · 2025Article
- Individual-level brain phenotypes in first-episode mania: normative modelling of brain morphometry and brainAGE.BJPsych open · 2025Article
- The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program.Schizophrenia (Heidelberg, Germany) · 2025Article
- Neurofind: using deep learning to make individualised inferences in brain-based disorders.Translational psychiatry · 2025Article
- Altered cortical thickness associated with psychotic symptoms and cognitive profiles in involuntarily hospitalized, first-episode, drug-naive patients with schizophrenia.Frontiers in psychiatry · 2025Article
- Parsing heterogeneity in global and local white matter integrity at different stages across the psychosis continuum.Schizophrenia (Heidelberg, Germany) · 2024Article
- Using brain structural neuroimaging measures to predict psychosis onset for individuals at clinical high-risk.Molecular psychiatry · 2024Article
- Personalized estimates of brain cortical structural variability in individuals with Autism spectrum disorder: the predictor of brain age and neurobiology relevance.Molecular autism · 2023Article
- Cumulative Impact of Morphometric Features in Schizophrenia in Two Independent Samples.Schizophrenia bulletin open · 2023Article
- Personalized estimates of morphometric similarity in multiple sclerosis and neuromyelitis optica spectrum disorders.NeuroImage. Clinical · 2023Article
- Parsing neurobiological heterogeneity of the clinical high-risk state for psychosis: A pseudo-continuous arterial spin labelling study.Frontiers in psychiatry · 2023Article
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Authors and funding
79 authors at 20 institutions in 18 countries.
Helen BaldwinEarly Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. helen.baldwin@kcl.ac.uk.ORCID 0000-0002-9507-9019
Joaquim RaduaEarly Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Mathilde AntoniadesDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Shalaila S HaasDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID 0000-0003-1385-1050
Sophia FrangouDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
Ingrid AgartzDepartment of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
Paul AllenDepartment of Psychology, University of Roehampton, London, UK.
Ole A AndreassenKG Jebsen Center for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway.ORCID 0000-0002-4461-3568
Kimberley AtkinsonDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Peter BachmanDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Inmaculada BaezaDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, 2017SGR-881, Hospital Clinic Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Universitat de Barcelona, Barcelona, Spain.
Cali F BartholomeuszCentre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia.
Michael W L CheeCenter for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-6087-0548
Tiziano ColibazziDepartment of Psychiatry, Columbia University, New York City, NY, USA.
Rebecca E CooperMelbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne & Melbourne Health, Carlton South, VIC, Australia.
Cheryl M CorcoranDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID 0000-0002-8902-4353
Vanessa L CropleyMelbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne & Melbourne Health, Carlton South, VIC, Australia.ORCID 0000-0003-0029-1525
Bjørn H EbdrupCentre for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, Copenhagen University Hospital, Glostrup, Denmark.ORCID 0000-0002-2590-5055
Adriana ForteaDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic Barcelona, Fundació Clínic Recerca Biomèdica, Universitat de Barcelona, Barcelona, Spain.
Louise Birkedal GlenthøjCopenhagen Research Center for Mental Health, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark.
Holly K HamiltonDepartment of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA.
Kristen M HautDepartment of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA.
Rebecca A HayesDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Ying HeNational Clinical Research Center for Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Karsten HeekerenDepartment of Psychiatry and Psychotherapy I, LVR-Hospital Cologne, Cologne, Germany.ORCID 0000-0001-5105-1922
Michael KaessDepartment of Child and Adolescent Psychiatry, Center of Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany.
Kiyoto KasaiDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-4443-4535
Naoyuki KatagiriDepartment of Neuropsychiatry, Toho University School of Medicine, Tokyo, Japan.
Minah KimDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.ORCID 0000-0001-8668-0817
Jochen KindlerUniversity Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Mallory J KlaunigDepartment of Psychology, University of Maryland, Baltimore County, MD, USA.
Shinsuke KoikeThe University of Tokyo Institute for Diversity and Adaptation of Human Mind, Tokyo, Japan.ORCID 0000-0002-3375-236X
Alex KoppelDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
Tina D KristensenCentre for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, Copenhagen University Hospital, Glostrup, Denmark.ORCID 0000-0001-9616-762X
Yoo Bin KwakDepartment of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.
Jun Soo KwonDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.ORCID 0000-0002-1060-1462
Stephen M LawrieDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-2444-5675
Irina LebedevaLaboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, Russian Federation.
Jimmy LeeDepartment of Psychosis, Institute of Mental Health, Singapore, Singapore.ORCID 0000-0002-7724-7445
Ashleigh LinTelethon Kids Institute, The University of Western Australia, Perth, WA, Australia.
Rachel L LoewyDepartment of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA.
Daniel H MathalonDepartment of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-6090-4974
Chantal MichelUniversity Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Romina MizrahiDouglas Research Center, Montreal, QC, Canada.ORCID 0000-0001-6667-7928
Paul MøllerDepartment for Mental Health Research and Development, Division of Mental Health and Addiction, Vestre Viken Hospital Trust, Drammen, Norway.
Barnaby NelsonCentre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia.
Takahiro NemotoDepartment of Neuropsychiatry, Toho University School of Medicine, Tokyo, Japan.ORCID 0000-0002-7318-7377
Dorte NordholmCopenhagen Research Center for Mental Health, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark.
Maria A OmelchenkoDepartment of Youth Psychiatry, Mental Health Research Center, Moscow, Russian Federation.
Christos PantelisMelbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne & Melbourne Health, Carlton South, VIC, Australia.ORCID 0000-0002-9565-0238
Jayachandra M RaghavaCentre for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, Copenhagen University Hospital, Glostrup, Denmark.
Jan I RøssbergNORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Wulf RösslerDepartment of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Dean F SalisburyDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Daiki SasabayashiDepartment of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.ORCID 0000-0001-8512-7438
Ulrich SchallPriority Centre for Brain and Mental Health Research, The University of Newcastle, Newcastle, NSW, Australia.
Lukasz SmigielskiDepartment of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-7428-7644
Gisela SugranyesDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, 2017SGR-881, Hospital Clinic Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Universitat de Barcelona, Barcelona, Spain.ORCID 0000-0002-2545-7862
Michio SuzukiDepartment of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.
Tsutomu TakahashiDepartment of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.ORCID 0000-0003-3213-6183
Christian K TamnesDepartment of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.ORCID 0000-0002-9191-6764
Jinsong TangDepartment of Psychiatry, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Anastasia TheodoridouDepartment of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-4792-385X
Sophia I ThomopoulosImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Alexander S TomyshevLaboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, Russian Federation.
Peter J UhlhaasInstitute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.
Tor G VærnesNORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Therese A M J van AmelsvoortDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Theo G M Van ErpCenter for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, CA, USA.ORCID 0000-0002-2465-2797
James A WaltzMaryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-9236-3719
Lars T WestlyeKG Jebsen Center for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway.ORCID 0000-0001-8644-956X
Stephen J WoodCentre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia.
Juan H ZhouCenter for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-0180-8648
Philip McGuireDepartment of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0003-4381-0532
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Maria JalbrzikowskiDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Dennis HernausDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
Paolo Fusar-PoliEarly Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
ENIGMA Clinical High Risk for Psychosis Working Group
The University of Melbourne · AUUniversity of Copenhagen · DKCentral South University · CNKing's College London · GBOslo University Hospital · NOInstituto Nacional de Neurología y Neurocirugía · MXSeoul National University · KRUniversity of Bern · CHUniversity of Pittsburgh · USUniversity of Zurich · CHMaastricht University · NLMental Health Research Center of Russian Academy of Medical Sciences · RUUniversity of California, San Francisco · USUniversity of Edinburgh · GBUniversity of Toyama · JPCentro de Investigación Biomédica en Red de Salud Mental · ESIcahn School of Medicine at Mount Sinai · USNational University of Singapore · SGRush University Medical Center · USThe University of Tokyo · JP
Funding
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2012 to 2022
$14.1MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MInstitutional Career Development Core (Chapter 1)KL2TR002387 · NCATS · UNIVERSITY OF CHICAGO · PI ERIC C BEYER, Lisa L Barnes · 2017 to 2026
$7.6MAuditory Cortex Connectivity in Emerging PsychosisR01MH113533 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SALISBURY, DEAN F · 2017 to 2021
$3.4MENIGMA World Aging CenterR01AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2021 to 2025
$3.3MThought disorder and social cognition in clinical risk states for schizophreniaR01MH107558 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI CORCORAN, CHERYL MARY · 2016 to 2020
$3.3MBrain connectivity and the role of myelin in PsychosisR01MH113619 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FRANGOU, SOPHIA · 2018 to 2021
$2.5MENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5MUsing the RDoC Approach to Understand Thought Disorder: A Linguistic Corpus-Based ApproachR01MH115332 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CORCORAN, CHERYL MARY · 2018 to 2020
$1.6MNeurodevelopmental variation of intrinsic functional connectivity and its relationship to psychosis risk and gene expression - SupplementK01MH112774 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JALBRZIKOWSKI, MARIA · 2017 to 2022
$884kMechanisms of copper dysregulation in schizophreniaR21MH117434 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROBERTS, ROSALINDA C · 2018 to 2019
$400kDepartment of HealthNCATS NIH HHS KL2 TR002387NIA NIH HHS R01 AG058854NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020403NIH HHS P41EB015922NIH HHS R01AG058854NIMH NIH HHS K01 MH112774NIMH NIH HHS R01 MH107558NIMH NIH HHS R01MH107558NIMH NIH HHS R01 MH113533NIMH NIH HHS R01 MH113619NIMH NIH HHS R01MH113619NIMH NIH HHS R01 MH115332NIMH NIH HHS R01MH115332NIMH NIH HHS R01 MH116147NIMH NIH HHS R01MH116147NIMH NIH HHS R21 MH117434
Abstract
Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely undetermined. We aimed to quantify the neuroanatomical heterogeneity in structural magnetic resonance imaging measures of cortical surface area (SA), cortical thickness (CT), subcortical volume (SV), and intracranial volume (ICV) in CHR-P individuals compared with healthy controls (HC), and in relation to subsequent transition to a first episode of psychosis. The ENIGMA CHR-P consortium applied a harmonised analysis to neuroimaging data across 29 international sites, including 1579 CHR-P individuals and 1243 HC, offering the largest pooled CHR-P neuroimaging dataset to date. Regional heterogeneity was indexed with the Variability Ratio (VR) and Coefficient of Variation (CV) ratio applied at the group level. Personalised estimates of heterogeneity of SA, CT and SV brain profiles were indexed with the novel Person-Based Similarity Index (PBSI), with two complementary applications. First, to assess the extent of within-diagnosis similarity or divergence of neuroanatomical profiles between individuals. Second, using a normative modelling approach, to assess the 'normativeness' of neuroanatomical profiles in individuals at CHR-P. CHR-P individuals demonstrated no greater regional heterogeneity after applying FDR corrections. However, PBSI scores indicated significantly greater neuroanatomical divergence in global SA, CT and SV profiles in CHR-P individuals compared with HC. Normative PBSI analysis identified 11 CHR-P individuals (0.70%) with marked deviation (>1.5 SD) in SA, 118 (7.47%) in CT and 161 (10.20%) in SV. Psychosis transition was not significantly associated with any measure of heterogeneity. Overall, our examination of neuroanatomical heterogeneity within the CHR-P state indicated greater divergence in neuroanatomical profiles at an individual level, irrespective of psychosis conversion. Further large-scale investigations are required of those who demonstrate marked deviation.
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Psychotic DisordersBrainHumansMagnetic Resonance Imaging
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