Evidence map›Paper›PMID 35882775›Full record

ArticleAdvances in experimental medicine and biology2022

Systematically Assessing Natural Compounds' Wound Healing Potential with Spheroid and Scratch Assays.

Gabriel Virador, Lisa Patel, Matthew Allen, Spencer Adkins, Miguel Virador, Derek Chen, Win Thant, Niloofar Tehrani, Victoria Virador

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Article in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gabriel ViradorUniversidad de Navarra, Pamplona, Spain.
Lisa PatelMontgomery College, Rockville, MD, USA.
Matthew AllenMontgomery College, Rockville, MD, USA.
Spencer AdkinsMontgomery College, Rockville, MD, USA.
Miguel ViradorMontgomery College, Rockville, MD, USA.
Derek ChenVirginia-Maryland Regional College of Veterinary Medicine, Blacksburg, VA, USA.
Win ThantMontgomery College, Rockville, MD, USA.
Niloofar TehraniMontgomery College, Rockville, MD, USA.
Victoria ViradorMontgomery College, Rockville, MD, USA. vvirador@montgomerycollege.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding cellular processes involved in wound healing is very important given that there are diseases, such as diabetes, in which wounds do not heal. To model tissue regeneration, we focus on two cellular processes: cellular proliferation, to replace cells lost to the wound, and cell motility, activated at the wound edges. We address these two processes in separate, drug responsive, in vitro models. The first model is a scaffold-free three-dimensional (3D) spheroid model, in which spheroids grow larger - to a certain extent - with increased time in culture. The second model, the scratch wound assay, is focused on cell motility. In conjunction with collagen staining, it analyzes changes to the coverage of the wound edge and wound bed. Our workflow gives insights into candidate compounds for wound healing as we show using manuka honey (MH) as an example. Spheroids are responsive to oxidative damage by hydrogen peroxide (H

Indexed as

HoneyCell MovementCell ProliferationHydrogen PeroxideWound HealingHydrogen PeroxideCollagen stainManuka honeyMurine stem cellsTissue regenerationViability

Identifiers

PMID35882775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.