Evidence map›Paper›PMID 35882772›Full record

ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2022

Sensitive and valid assay for reliable evaluation of drug interactions mediated by human organic anion transporter 1 and 3 using 5-carboxyfluorescein.

Kyeong-Ryoon Lee, Ji-Eun Chang, Yoon-Jee Chae

Abstract read
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In one paragraph

Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Kyeong-Ryoon Lee *Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, 28116, Republic of Korea.
Ji-Eun Chang *College of Pharmacy, Dongduk Women's University, Seoul, 02748, Republic of Korea.
Yoon-Jee ChaeCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Woosuk University, Wanju, 55338, Republic of Korea. yjchae@woosuk.ac.kr.ORCID http://orcid.org/0000-0003-4921-4192
Dongduk Women's University · KRKorea Research Institute of Bioscience and Biotechnology · KRWoosuk University · KR

Funding

Ministry of Trade, Industry, and Energy nos. 20009774National Research Foundation 2021R1I1A3056261
6 · The paper itself

Abstract

Drug interactions can induce significant clinical impacts, either by increasing adverse effects or by decreasing the therapeutic effect of drugs, and thus, need to be explored thoroughly. Clinically significant drug interactions can be induced by organic anion transporter 1 (OAT1) and OAT3 when concomitant medications competitively interact with the transporters. The purposes of this study were to develop and validate a sensitive and selective analytical method for 5-carboxyfluorescein (5-CF) and optimize the experimental conditions for interaction studies. An analytical method using high-performance liquid chromatography (HPLC) equipped with a fluorescence detector was validated for accuracy, precision, matrix effect, recovery, stability, dilutional integrity, and carry-over effect. In addition, the 5-CF concentration, incubation period, and washing conditions for interaction study were optimized. Using a valid analytical method and optimized conditions, we performed an interaction study for OAT1 and OAT3 using 26 test articles. Some of the test articles showed strong inhibitory potency for the transporters, with IC

Indexed as

Organic Anion Transporters, Sodium-IndependentOrganic Anion Transport Protein 1Drug InteractionsFluoresceinsHumans4-carboxyfluoresceinFluoresceinsOrganic Anion Transporters, Sodium-IndependentOrganic Anion Transport Protein 15-carboxyfluorescein (5-CF)Drug interactionsHigh-performance liquid chromatography (HPLC)Method validationOrganic anion transporters (OATs)

Identifiers

PMID35882772
OpenAlexW4288174762

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.