Evidence map›Paper›PMID 35882762›Full record

ArticleBrain imaging and behavior2022

Reduced structural integrity of the uncinate fasciculus in incarcerated women scoring high on psychopathy.

J Michael Maurer, Subhadip Paul, Bethany G Edwards, Nathaniel E Anderson, Prashanth K Nyalakanti, Carla L Harenski, Jean Decety, Kent A Kiehl

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain imaging and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

J Michael MaurerThe Mind Research Network, 1101 Yale Boulevard NE, Albuquerque, NM, 87106, USA. mmaurer@mrn.org.ORCID http://orcid.org/0000-0002-2214-2435
Subhadip PaulSchool of Biological Sciences, Ramakrishna Mission Vivekananda Educational and Research Institute (RKMVERI), Narendrapur, Kolkata, West Bengal, India.
Bethany G EdwardsThe Mind Research Network, 1101 Yale Boulevard NE, Albuquerque, NM, 87106, USA.
Nathaniel E AndersonThe Mind Research Network, 1101 Yale Boulevard NE, Albuquerque, NM, 87106, USA.
Prashanth K NyalakantiThe Mind Research Network, 1101 Yale Boulevard NE, Albuquerque, NM, 87106, USA.
Carla L HarenskiThe Mind Research Network, 1101 Yale Boulevard NE, Albuquerque, NM, 87106, USA.
Jean DecetyDepartment of Psychology, Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
Kent A KiehlThe Mind Research Network, 1101 Yale Boulevard NE, Albuquerque, NM, 87106, USA. kkiehl@mrn.org.

Funding

Cloud based neuroimaging analysis for identifying traumatic braininjuries and related changesR01NS126742 · NINDS · LOVELACE BIOMEDICAL RESEARCH INSTITUTE · PI KENT A KIEHL, Michael R. Koenigs · 2022 to 2026
$3.8M
Socioemotional processing in female offenders - Resubmission 01R01MH109329 · NIMH · UNIVERSITY OF CHICAGO · PI DECETY, JEAN, KIEHL, KENT A · 2016 to 2020
$3.6M
The Cognitive Neuroscience of Female PsychopathyR01MH085010 · NIMH · THE MIND RESEARCH NETWORK · PI KIEHL, KENT A · 2009 to 2013
$3.2M
Neurocognitive Changes Associated with Behavioral Treatment in Cocaine AbusersR01DA020870 · NIDA · THE MIND RESEARCH NETWORK · PI KIEHL, KENT A · 2005 to 2009
$3.0M
Action Monitoring, Action Observation and Dopamine Genes as Predictors of SubstanR01DA026964 · NIDA · THE MIND RESEARCH NETWORK · PI KIEHL, KENT A · 2010 to 2014
$2.9M
NIDA NIH HHS R01 DA020870NIDA NIH HHS R01 DA026964NIMH NIH HHS R01 MH085010NIMH NIH HHS R01 MH109329NINDS NIH HHS R01 NS126742
6 · The paper itself

Abstract

Both men and women scoring high on psychopathy exhibit similar structural and functional neural abnormalities, including reduced volume of the orbitofrontal cortex (OFC) and reduced hemodynamic activity in the amygdala during affective processing experimental paradigms. The uncinate fasciculus (UF) is a white matter (WM) tract that connects the amygdala to the OFC. Reduced structural integrity of the UF, measured via fractional anisotropy (FA), is commonly associated with men scoring high on psychopathy. However, only one study to date has investigated the relationship between psychopathic traits and UF structural integrity in women, recruiting participants from a community sample. Here, we investigated whether Hare Psychopathy Checklist-Revised (PCL-R) facet scores (measuring interpersonal, affective, lifestyle/behavioral, and antisocial psychopathic traits, respectively) were associated with reduced FA in the left and right UF in a sample of 254 incarcerated women characterized by a wide range of psychopathy scores. We observed that PCL-R Facet 3 scores, assessing lifestyle/behavioral psychopathic traits, were associated with reduced FA in the left and right UF, even when controlling for participant's age and history of previous substance use. The results obtained in the current study help improve our understanding of structural abnormalities associated with women scoring high on psychopathy. Specifically, reduced UF structural integrity may contribute to some of the deficits commonly associated with women scoring high on psychopathy, including emotion dysregulation.

Indexed as

PrisonersWhite MatterDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleUncinate FasciculusDiffusion tensor imagingFemale psychopathyFractional anisotropyUncinate fasciculus

Identifiers

PMID35882762
PMCPMC11423388

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.