Evidence map›Paper›PMID 35882745›Full record

ArticleMolecular biology reports2022

The anti-inflamatory effect of Andira anthelmia lectin in rats involves inhibition of the prostanoid pathway, TNF-α and lectin domain.

Francisco Lucas Faustino do Nascimento, Alana de Freitas Pires, Mário Rogério Lima Mota, Pedro Henrique Chaves Isaias, Diego Freitas de Araujo, Maria Gleiciane de Queiroz Martins, Cleane Gomes Moreira, João Batista Cajazeiras, Benildo Sousa Cavada, Kyria Santiago do Nascimento and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Francisco Lucas Faustino do NascimentoLaboratório de Fisio-Farmacologia da Inflamação (LAFFIN), Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Av. Dr. Silas Munguba 1700, Fortaleza, CE, CEP 60740-000, Brazil.
Alana de Freitas PiresLaboratório de Fisio-Farmacologia da Inflamação (LAFFIN), Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Av. Dr. Silas Munguba 1700, Fortaleza, CE, CEP 60740-000, Brazil.
Mário Rogério Lima MotaDepartamento de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará, Rua Alexandre Baraúna 949, Fortaleza, CE, CEP 60430-170, Brazil.
Pedro Henrique Chaves IsaiasDepartamento de Farmácia, Odontologia e Enfermagem, Universidade Federal do Ceará, Rua Alexandre Baraúna 949, Fortaleza, CE, CEP 60430-170, Brazil.
Diego Freitas de AraujoLaboratório de Fisio-Farmacologia da Inflamação (LAFFIN), Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Av. Dr. Silas Munguba 1700, Fortaleza, CE, CEP 60740-000, Brazil.
Maria Gleiciane de Queiroz MartinsDepartamento de Bioquímica E Biologia Molecular, Laboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Universidade Federal do Ceará, Campus do Pici, s/n; Bloco 907, Fortaleza, CE, CEP 60440-970, Brazil.
Cleane Gomes MoreiraDepartamento de Bioquímica E Biologia Molecular, Laboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Universidade Federal do Ceará, Campus do Pici, s/n; Bloco 907, Fortaleza, CE, CEP 60440-970, Brazil.
João Batista CajazeirasDepartamento de Bioquímica E Biologia Molecular, Laboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Universidade Federal do Ceará, Campus do Pici, s/n; Bloco 907, Fortaleza, CE, CEP 60440-970, Brazil.
Benildo Sousa CavadaDepartamento de Bioquímica E Biologia Molecular, Laboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Universidade Federal do Ceará, Campus do Pici, s/n; Bloco 907, Fortaleza, CE, CEP 60440-970, Brazil.
Kyria Santiago do NascimentoDepartamento de Bioquímica E Biologia Molecular, Laboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Universidade Federal do Ceará, Campus do Pici, s/n; Bloco 907, Fortaleza, CE, CEP 60440-970, Brazil. kyriasantiago@gmail.com.
Ana Maria Sampaio AssreuyLaboratório de Fisio-Farmacologia da Inflamação (LAFFIN), Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Av. Dr. Silas Munguba 1700, Fortaleza, CE, CEP 60740-000, Brazil. anassreuy@gmail.com.ORCID http://orcid.org/0000-0002-2323-5385
Universidade Federal do Ceará · BRUniversidade Estadual do Ceará · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 308433/2017-3
6 · The paper itself

Abstract

objectiveTo investigate the effect and mechanisms of Andira anthelmia lectin in rat models of acute inflammation. MATERIAL: AAL anti-inflammatory activity was evaluated in Wistar rat models of paw edema and peritonitis.

methodsAAL (0.01-1 mg/kg i.v.) was injected 30 min before stimulation with carrageenan and with initial and late phase inflammatory mediators into the animals paw or peritoneum for evaluation of cell migration (optical and intravital microscopy), paw edema (plethysmometry and histopathology); hyperalgesia (analgesimetry).

resultsAAL inhibited leukocyte migration induced by carrageenan, mainly neutrophils to the peritoneal fluid, decreasing leukocyte adhesion. In the peritoneal fluid, AAL reduced the gene expression of TNF-α and cyclooxygenase, as well the levels of PGE

conclusionAAL presents anti-inflammatory effect in acute models of rat inflammation involving the participation of prostaglandins, TNF-α and lectin domain.

Indexed as

FabaceaeTumor Necrosis Factor-alphaAnimalsAnti-Inflammatory AgentsCarrageenanDinoprostoneEdemaInflammationLectinsProstaglandinsRatsRats, WistarAnti-Inflammatory AgentsCarrageenanDinoprostoneLectinsProstaglandinsTumor Necrosis Factor-alphaAcute inflammationDalbergieaePlant lectinProstaglandinsTNF-α

Identifiers

PMID35882745
OpenAlexW4288069118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.