ArticleEuropean radiology experimental2022
Photon-counting detector CT and energy-integrating detector CT for trabecular bone microstructure analysis of cubic specimens from human radius.
Article in European radiology experimental, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Review
- Photon-counting CT-guided bone biopsy with real-time bone marrow edema mapping.European radiology experimental · 2026Article
- Agreement between in vivo and ex vivo photon-counting CT measurements of subchondral trabecular bone features in patients with knee osteoarthritis.European radiology · 2026Article
- Trabecular bone analysis: ultra-high-resolution CT goes far beyond high-resolution CT and gets closer to micro-CT (a study using Canon Medical CT devices).Skeletal radiology · 2026Article
- TranslatingFrontiers in bioengineering and biotechnology · 2026Article
- Photon-Counting CT in Musculoskeletal Radiology: Technical Principles, Clinical Applications, and Future Directions.Journal of the Belgian Society of Radiology · 2026Review
- A novel computed tomography-based algorithm for the quantitative identification of lumbar spine-localized trabecular bone loss in patients with type 2 diabetes mellitus.Quantitative imaging in medicine and surgery · 2026Article
- Photon-counting detector CT: a disrupting innovation in medical imaging.European radiology experimental · 2025Article
- Quantitative metrics of bone quality determined at the distal radius using photon-counting CT.Skeletal radiology · 2025Article
- Minimal Detectable Bone Fracture Gaps in CT Images and Digital Three-Dimensional (3D) Radii Models.Journal of imaging informatics in medicine · 2025Article
- Ultrasound-based jawbone surface quality evaluation after alveolar ridge preservation.Journal of periodontology · 2024Article
- Photon-Counting Computed Tomography for Microstructural Imaging of Bone and Joints.Current osteoporosis reports · 2024Review
- Opportunistic use of chest low-dose computed tomography (LDCT) imaging for low bone mineral density and osteoporosis screening: cutoff thresholds for the attenuation values of the lower thoracic and upper lumbar vertebrae.Quantitative imaging in medicine and surgery · 2024Article
- Automated region growing-based segmentation for trabecular bone structure in fresh-frozen human wrist specimens.BMC medical imaging · 2024Article
- Comparison of Bone Evaluation and Metal Artifact between Photon-Counting CT and Five Energy-Integrating-Detector CT under Standardized Conditions Using Cadaveric Forearms.Diagnostics (Basel, Switzerland) · 2024Article
- [A comprehensive review on photon-counting computed tomography: Principles, technical hurdles and analysis of clinical applications].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2023Review
- Imaging in inflammatory arthritis: progress towards precision medicine.Nature reviews. Rheumatology · 2023Review
- Milestones in CT: Past, Present, and Future.Radiology · 2023Review
- Clinical Applications of Photon-counting CT: A Review of Pioneer Studies and a Glimpse into the Future.Radiology · 2023Review
- Clinical applications of photon counting detector CT.European radiology · 2023Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs bone microstructure is known to impact bone strength, the aim of this in vitro study was to evaluate if the emerging photon-counting detector computed tomography (PCD-CT) technique may be used for measurements of trabecular bone structures like thickness, separation, nodes, spacing and bone volume fraction.
methodsFourteen cubic sections of human radius were scanned with two multislice CT devices, one PCD-CT and one energy-integrating detector CT (EID-CT), using micro-CT as a reference standard. The protocols for PCD-CT and EID-CT were those recommended for inner- and middle-ear structures, although at higher mAs values: PCD-CT at 450 mAs and EID-CT at 600 (dose equivalent to PCD-CT) and 1000 mAs. Average measurements of the five bone parameters as well as dispersion measurements of thickness, separation and spacing were calculated using a three-dimensional automated region growing (ARG) algorithm. Spearman correlations with micro-CT were computed.
resultsCorrelations with micro-CT, for PCD-CT and EID-CT, ranged from 0.64 to 0.98 for all parameters except for dispersion of thickness, which did not show a significant correlation (p = 0.078 to 0.892). PCD-CT had seven of the eight parameters with correlations ρ > 0.7 and three ρ > 0.9. The dose-equivalent EID-CT instead had four parameters with correlations ρ > 0.7 and only one ρ > 0.9.
conclusionsIn this in vitro study of radius specimens, strong correlations were found between trabecular bone structure parameters computed from PCD-CT data when compared to micro-CT. This suggests that PCD-CT might be useful for analysing bone microstructure in the peripheral human skeleton.
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